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- W2169094222 abstract "We used an antithrombin autoantibody (IgG D), the epitope of which encompasses ABE1 and amino acids located within variable region 1, to study thrombin interactions with R358 alpha 1-AT and protein C. IgG D inhibited the thrombin interaction with R358 alpha 1-AT, while hirugen had no effect, indicating that the interaction of R358 alpha 1-AT with thrombin may involve the VR1 subsite. We also obtained evidence that VR1 may be involved in the activation of protein C by thrombin in the absence of thrombomodulin. Moreover, IgG D attenuated the inhibitory effect of calcium ions during protein C activation by thrombin, probably by masking E39 within the VR1 site." @default.
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- W2169094222 date "1995-05-29" @default.
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- W2169094222 title "Human thrombin variable region 1, including E39, is involved in interactions with α1-antitrypsin M358R and protein C" @default.
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- W2169094222 doi "https://doi.org/10.1016/0014-5793(95)00457-k" @default.
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