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• W2169103586 abstract "Abstract Background A recently published genome-wide association study (GWAS) of late-onset Alzheimer's disease (LOAD) revealed genome-wide significant association of variants in or near MS4A4A, CD2AP, EPHA1 and CD33 . Meta-analyses of this and a previously published GWAS revealed significant association at ABCA7 and MS4A , independent evidence for association of CD2AP, CD33 and EPHA1 and an opposing yet significant association of a variant near ARID5B . In this study, we genotyped five variants (in or near CD2AP, EPHA1, ARID5B , and CD33 ) in a large (2,634 LOAD, 4,201 controls), independent dataset comprising six case-control series from the USA and Europe. We performed meta-analyses of the association of these variants with LOAD and tested for association using logistic regression adjusted by age-at-diagnosis, gender, and APOE ε4 dosage. Results We found no significant evidence of series heterogeneity. Associations with LOAD were successfully replicated for EPHA1 (rs11767557; OR = 0.87, p = 5 × 10 -4 ) and CD33 (rs3865444; OR = 0.92, p = 0.049), with odds ratios comparable to those previously reported. Although the two ARID5B variants (rs2588969 and rs494288) showed significant association with LOAD in meta-analysis of our dataset (p = 0.046 and 0.008, respectively), the associations did not survive adjustment for covariates (p = 0.30 and 0.11, respectively). We had insufficient evidence in our data to support the association of the CD2AP variant (rs9349407, p = 0.56). Conclusions Our data overwhelmingly support the association of EPHA1 and CD33 variants with LOAD risk: addition of our data to the results previously reported (total n > 42,000) increased the strength of evidence for these variants, providing impressive p-values of 2.1 × 10 -15 ( EPHA1 ) and 1.8 × 10 -13 ( CD33 )." @default.
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• W2169103586 date "2011-07-28" @default.
• W2169103586 modified "2023-09-26" @default.
• W2169103586 title "Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study" @default.
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• W2169103586 doi "https://doi.org/10.1186/1750-1326-6-54" @default.
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