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- W2169108775 abstract "In mammals, cadmium is widely considered as a non-genotoxic carcinogen acting through a methylation-dependent epigenetic mechanism. Here, the effects of Cd treatment on the DNA methylation patten are examined together with its effect on chromatin reconfiguration in Posidonia oceanica. DNA methylation level and pattern were analysed in actively growing organs, under short- (6 h) and long- (2 d or 4 d) term and low (10 μM) and high (50 μM) doses of Cd, through a Methylation-Sensitive Amplification Polymorphism technique and an immunocytological approach, respectively. The expression of one member of the CHROMOMETHYLASE (CMT) family, a DNA methyltransferase, was also assessed by qRT-PCR. Nuclear chromatin ultrastructure was investigated by transmission electron microscopy. Cd treatment induced a DNA hypermethylation, as well as an up-regulation of CMT, indicating that de novo methylation did indeed occur. Moreover, a high dose of Cd led to a progressive heterochromatinization of interphase nuclei and apoptotic figures were also observed after long-term treatment. The data demonstrate that Cd perturbs the DNA methylation status through the involvement of a specific methyltransferase. Such changes are linked to nuclear chromatin reconfiguration likely to establish a new balance of expressed/repressed chromatin. Overall, the data show an epigenetic basis to the mechanism underlying Cd toxicity in plants." @default.
- W2169108775 created "2016-06-24" @default.
- W2169108775 creator A5002146575 @default.
- W2169108775 creator A5064409169 @default.
- W2169108775 creator A5076435201 @default.
- W2169108775 creator A5082374617 @default.
- W2169108775 date "2011-11-04" @default.
- W2169108775 modified "2023-10-01" @default.
- W2169108775 title "In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning" @default.
- W2169108775 cites W116253160 @default.
- W2169108775 cites W1489551155 @default.
- W2169108775 cites W1500702901 @default.
- W2169108775 cites W1516768294 @default.
- W2169108775 cites W1736253400 @default.
- W2169108775 cites W1916132949 @default.
- W2169108775 cites W1964271596 @default.
- W2169108775 cites W1965428844 @default.
- W2169108775 cites W1966661220 @default.
- W2169108775 cites W1977171359 @default.
- W2169108775 cites W1978898519 @default.
- W2169108775 cites W1980090230 @default.
- W2169108775 cites W1982915180 @default.
- W2169108775 cites W1984251741 @default.
- W2169108775 cites W1991021666 @default.
- W2169108775 cites W1993336272 @default.
- W2169108775 cites W1994407254 @default.
- W2169108775 cites W1994965079 @default.
- W2169108775 cites W1998220913 @default.
- W2169108775 cites W1998517881 @default.
- W2169108775 cites W1998757028 @default.
- W2169108775 cites W2001476164 @default.
- W2169108775 cites W2004873261 @default.
- W2169108775 cites W2006342727 @default.
- W2169108775 cites W2006414404 @default.
- W2169108775 cites W2007862296 @default.
- W2169108775 cites W2009029658 @default.
- W2169108775 cites W2009505082 @default.
- W2169108775 cites W2011515533 @default.
- W2169108775 cites W2012865420 @default.
- W2169108775 cites W2013033579 @default.
- W2169108775 cites W2016618668 @default.
- W2169108775 cites W2019143225 @default.
- W2169108775 cites W2019438362 @default.
- W2169108775 cites W2026175443 @default.
- W2169108775 cites W2027589668 @default.
- W2169108775 cites W2033285747 @default.
- W2169108775 cites W2033350533 @default.
- W2169108775 cites W2037327312 @default.
- W2169108775 cites W2037797217 @default.
- W2169108775 cites W2042461047 @default.
- W2169108775 cites W2042548000 @default.
- W2169108775 cites W2044424039 @default.
- W2169108775 cites W2050507681 @default.
- W2169108775 cites W2051440315 @default.
- W2169108775 cites W2052230594 @default.
- W2169108775 cites W2054533705 @default.
- W2169108775 cites W2055565613 @default.
- W2169108775 cites W2056558303 @default.
- W2169108775 cites W2057162139 @default.
- W2169108775 cites W2064977063 @default.
- W2169108775 cites W2065706688 @default.
- W2169108775 cites W2067960860 @default.
- W2169108775 cites W2069503557 @default.
- W2169108775 cites W2072187563 @default.
- W2169108775 cites W2072339231 @default.
- W2169108775 cites W2076911571 @default.
- W2169108775 cites W2077235164 @default.
- W2169108775 cites W2077784322 @default.
- W2169108775 cites W2078394714 @default.
- W2169108775 cites W2081231125 @default.
- W2169108775 cites W2081643249 @default.
- W2169108775 cites W2084225936 @default.
- W2169108775 cites W2085103732 @default.
- W2169108775 cites W2088446803 @default.
- W2169108775 cites W2089146587 @default.
- W2169108775 cites W2090379876 @default.
- W2169108775 cites W2091234881 @default.
- W2169108775 cites W2093607065 @default.
- W2169108775 cites W2093685563 @default.
- W2169108775 cites W2095118217 @default.
- W2169108775 cites W2095359906 @default.
- W2169108775 cites W2098924542 @default.
- W2169108775 cites W2101814858 @default.
- W2169108775 cites W2107277218 @default.
- W2169108775 cites W2107938410 @default.
- W2169108775 cites W2114055738 @default.
- W2169108775 cites W2114973741 @default.
- W2169108775 cites W2115588584 @default.
- W2169108775 cites W2121304801 @default.
- W2169108775 cites W2125432724 @default.
- W2169108775 cites W2126371676 @default.
- W2169108775 cites W2126606466 @default.
- W2169108775 cites W2127471616 @default.
- W2169108775 cites W2134224159 @default.
- W2169108775 cites W2135851907 @default.
- W2169108775 cites W2136311892 @default.
- W2169108775 cites W2136640690 @default.
- W2169108775 cites W2138766691 @default.