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• W2169124865 abstract "Metabolic syndrome (MS) is a cluster of metabolic perturbations reflecting insulin resistance, i.e. central obesity, hypertriglyceridemia, reduced HDL cholesterol, hypertension, and glucose intolerance [ [1] Alberti K.G. Eckel R.H. Grundy S.M. et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120: 1640-1645 Crossref PubMed Scopus (9844) Google Scholar ]. MS is associated with a heightened risk of developing type 2 diabetes mellitus (DM) and cardiovascular disease. Several studies reported that MS significantly impacts clinical outcomes after cardiac surgery, and is an independent predictor of post-operative atrial fibrillation (POAF), the most common post-operative complication [ 2 Echahidi N. Mohty D. Pibarot P. et al. Obesity and metabolic syndrome are independent risk factors for atrial fibrillation after coronary artery bypass graft surgery. Circulation. 2007; 116: I213-I219 Crossref PubMed Scopus (151) Google Scholar , 3 Girerd N. Pibarot P. Fournier D. et al. Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery. Eur Heart J. 2009; 30: 1270-1278 Crossref PubMed Scopus (74) Google Scholar , 4 Angeloni E. Melina G. Benedetto U. et al. Metabolic syndrome affects midterm outcome after coronary artery bypass grafting. Ann Thorac Surg. 2012; 93: 537-544 Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar , 5 Echahidi N. Pibarot P. Després J.P. et al. Metabolic syndrome increases operative mortality in patients undergoing coronary artery bypass grafting surgery. J Am Coll Cardiol. 2007; 50: 843-851 Abstract Full Text Full Text PDF PubMed Scopus (87) Google Scholar ]. The specific link between MS, DM and POAF may have been blurred by the inclusion in the aforementioned studies of a large number of patent diabetic patients in MS groups since half of them had already transitioned from beginning insulin resistance to DM. Indeed, patients with type 2 DM are not excluded from the definition of metabolic syndrome in either ATPIII or IDF criteria [ [1] Alberti K.G. Eckel R.H. Grundy S.M. et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120: 1640-1645 Crossref PubMed Scopus (9844) Google Scholar ], and consequently, most patients with type 2 DM can in fact be identified with the various criteria for the diagnosis MS." @default.
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• W2169124865 date "2013-09-01" @default.
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• W2169124865 title "Contrasting effects of diabetes and metabolic syndrome on post-operative atrial fibrillation and in-hospital outcome after cardiac surgery" @default.
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