FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169129743> ?p ?o ?g. }

• W2169129743 endingPage "2672" @default.
• W2169129743 startingPage "2663" @default.
• W2169129743 abstract "ABSTRACT The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to investigate E2F3's role in vivo. We show that E2F3 is essential for embryonic viability in the pure 129/Sv background but the presence of C57BL/6 alleles yields some adult survivors. Although growth retarded, surviving E2f3 −/− animals are initially healthy. However, they die prematurely, exhibiting no obvious tumor phenotype but with the typical signs of congestive heart failure. The defects are completely distinct from those arising in E2f1 mutant mice (S. J. Field et al., Cell 85:549-561; 1996; L. Yamasaki et al., Cell 85:537-548, 1996), supporting the prevailing view that these E2Fs must have some unique biological functions in vivo. To test this model, we examined the phenotypes of E2f1 E2f3 compound mutant mice. Almost all of the developmental and age-related defects arising in the individual E2f1 or E2f3 mice were exacerbated by the mutation of the other E2f . Thus, E2F1 and E2F3 appear to play critical, overlapping roles in the development and maintenance of a variety of tissues. Importantly, this study did identify one major difference in the properties of E2F1 and E2F3: either alone or in combination with E2F1 loss, E2f3 mutation did not increase the incidence of tumor formation. These data strongly suggest that tumor suppression is a specific property of E2F1 and not E2F3." @default.
• W2169129743 created "2016-06-24" @default.
• W2169129743 creator A5013479170 @default.
• W2169129743 creator A5015397547 @default.
• W2169129743 creator A5016136470 @default.
• W2169129743 creator A5025208588 @default.
• W2169129743 creator A5026855923 @default.
• W2169129743 creator A5034177116 @default.
• W2169129743 creator A5045638080 @default.
• W2169129743 creator A5054412365 @default.
• W2169129743 creator A5085454999 @default.
• W2169129743 date "2002-04-01" @default.
• W2169129743 modified "2023-10-14" @default.
• W2169129743 title "Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo" @default.
• W2169129743 cites W1496643658 @default.
• W2169129743 cites W1606907359 @default.
• W2169129743 cites W1634638391 @default.
• W2169129743 cites W1635667563 @default.
• W2169129743 cites W1665024321 @default.
• W2169129743 cites W1762601366 @default.
• W2169129743 cites W1834185815 @default.
• W2169129743 cites W1897206684 @default.
• W2169129743 cites W1937375640 @default.
• W2169129743 cites W1965080968 @default.
• W2169129743 cites W1980759602 @default.
• W2169129743 cites W1983287898 @default.
• W2169129743 cites W1983971803 @default.
• W2169129743 cites W1989129860 @default.
• W2169129743 cites W1992802797 @default.
• W2169129743 cites W2001627329 @default.
• W2169129743 cites W2009214757 @default.
• W2169129743 cites W2009910507 @default.
• W2169129743 cites W2027884200 @default.
• W2169129743 cites W2029631901 @default.
• W2169129743 cites W2029954359 @default.
• W2169129743 cites W2034277114 @default.
• W2169129743 cites W2042717737 @default.
• W2169129743 cites W2046841127 @default.
• W2169129743 cites W2048513196 @default.
• W2169129743 cites W2053881125 @default.
• W2169129743 cites W2055162988 @default.
• W2169129743 cites W2055270107 @default.
• W2169129743 cites W2061665609 @default.
• W2169129743 cites W2064550856 @default.
• W2169129743 cites W2066125587 @default.
• W2169129743 cites W2066980099 @default.
• W2169129743 cites W2070677152 @default.
• W2169129743 cites W2071373462 @default.
• W2169129743 cites W2080758883 @default.
• W2169129743 cites W2098470595 @default.
• W2169129743 cites W2106157678 @default.
• W2169129743 cites W2107997806 @default.
• W2169129743 cites W2114738441 @default.
• W2169129743 cites W2118498323 @default.
• W2169129743 cites W2125072003 @default.
• W2169129743 cites W2126133348 @default.
• W2169129743 cites W2132526380 @default.
• W2169129743 cites W2133609791 @default.
• W2169129743 cites W2135789424 @default.
• W2169129743 cites W2145363003 @default.
• W2169129743 cites W2146453903 @default.
• W2169129743 cites W2147131744 @default.
• W2169129743 cites W2149139293 @default.
• W2169129743 cites W2152432521 @default.
• W2169129743 cites W2152616419 @default.
• W2169129743 cites W2155463318 @default.
• W2169129743 cites W2158269177 @default.
• W2169129743 cites W2161545898 @default.
• W2169129743 cites W2324510594 @default.
• W2169129743 doi "https://doi.org/10.1128/mcb.22.8.2663-2672.2002" @default.
• W2169129743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133738" @default.
• W2169129743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11909960" @default.
• W2169129743 hasPublicationYear "2002" @default.
• W2169129743 type Work @default.
• W2169129743 sameAs 2169129743 @default.
• W2169129743 citedByCount "87" @default.
• W2169129743 countsByYear W21691297432012 @default.
• W2169129743 countsByYear W21691297432013 @default.
• W2169129743 countsByYear W21691297432014 @default.
• W2169129743 countsByYear W21691297432015 @default.
• W2169129743 countsByYear W21691297432016 @default.
• W2169129743 countsByYear W21691297432017 @default.
• W2169129743 countsByYear W21691297432018 @default.
• W2169129743 countsByYear W21691297432019 @default.
• W2169129743 countsByYear W21691297432020 @default.
• W2169129743 countsByYear W21691297432021 @default.
• W2169129743 countsByYear W21691297432022 @default.
• W2169129743 countsByYear W21691297432023 @default.
• W2169129743 crossrefType "journal-article" @default.
• W2169129743 hasAuthorship W2169129743A5013479170 @default.
• W2169129743 hasAuthorship W2169129743A5015397547 @default.
• W2169129743 hasAuthorship W2169129743A5016136470 @default.
• W2169129743 hasAuthorship W2169129743A5025208588 @default.
• W2169129743 hasAuthorship W2169129743A5026855923 @default.
• W2169129743 hasAuthorship W2169129743A5034177116 @default.
• W2169129743 hasAuthorship W2169129743A5045638080 @default.
• W2169129743 hasAuthorship W2169129743A5054412365 @default.
• W2169129743 hasAuthorship W2169129743A5085454999 @default.

• next