FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169137344> ?p ?o ?g. }

• W2169137344 endingPage "e315" @default.
• W2169137344 startingPage "e315" @default.
• W2169137344 abstract "Animal circadian clocks are based on multiple oscillators whose interactions allow the daily control of complex behaviors. The Drosophila brain contains a circadian clock that controls rest–activity rhythms and relies upon different groups of PERIOD (PER)–expressing neurons. Two distinct oscillators have been functionally characterized under light-dark cycles. Lateral neurons (LNs) that express the pigment-dispersing factor (PDF) drive morning activity, whereas PDF-negative LNs are required for the evening activity. In constant darkness, several lines of evidence indicate that the LN morning oscillator (LN-MO) drives the activity rhythms, whereas the LN evening oscillator (LN-EO) does not. Since mutants devoid of functional CRYPTOCHROME (CRY), as opposed to wild-type flies, are rhythmic in constant light, we analyzed transgenic flies expressing PER or CRY in the LN-MO or LN-EO. We show that, under constant light conditions and reduced CRY function, the LN evening oscillator drives robust activity rhythms, whereas the LN morning oscillator does not. Remarkably, light acts by inhibiting the LN-MO behavioral output and activating the LN-EO behavioral output. Finally, we show that PDF signaling is not required for robust activity rhythms in constant light as opposed to its requirement in constant darkness, further supporting the minor contribution of the morning cells to the behavior in the presence of light. We therefore propose that day–night cycles alternatively activate behavioral outputs of the Drosophila evening and morning lateral neurons." @default.
• W2169137344 created "2016-06-24" @default.
• W2169137344 creator A5020316144 @default.
• W2169137344 creator A5021755079 @default.
• W2169137344 creator A5036989414 @default.
• W2169137344 creator A5072616070 @default.
• W2169137344 creator A5085432609 @default.
• W2169137344 date "2007-11-27" @default.
• W2169137344 modified "2023-10-11" @default.
• W2169137344 title "Light Activates Output from Evening Neurons and Inhibits Output from Morning Neurons in the Drosophila Circadian Clock" @default.
• W2169137344 cites W1484069803 @default.
• W2169137344 cites W1492540368 @default.
• W2169137344 cites W1659345007 @default.
• W2169137344 cites W1964557069 @default.
• W2169137344 cites W1986877101 @default.
• W2169137344 cites W1987956257 @default.
• W2169137344 cites W1992414745 @default.
• W2169137344 cites W1998371106 @default.
• W2169137344 cites W1999616919 @default.
• W2169137344 cites W2021500478 @default.
• W2169137344 cites W2023008210 @default.
• W2169137344 cites W2049253094 @default.
• W2169137344 cites W2051354017 @default.
• W2169137344 cites W2052267173 @default.
• W2169137344 cites W2056498650 @default.
• W2169137344 cites W2060904873 @default.
• W2169137344 cites W2069102506 @default.
• W2169137344 cites W2071250433 @default.
• W2169137344 cites W2079883670 @default.
• W2169137344 cites W2089166645 @default.
• W2169137344 cites W2091953892 @default.
• W2169137344 cites W2095299680 @default.
• W2169137344 cites W2101315076 @default.
• W2169137344 cites W2113526393 @default.
• W2169137344 cites W2114427883 @default.
• W2169137344 cites W2121639331 @default.
• W2169137344 cites W2136757266 @default.
• W2169137344 cites W2139819456 @default.
• W2169137344 cites W2140779941 @default.
• W2169137344 cites W2151305846 @default.
• W2169137344 cites W2154832783 @default.
• W2169137344 cites W2161168395 @default.
• W2169137344 cites W2167234212 @default.
• W2169137344 cites W2181805551 @default.
• W2169137344 cites W2768954983 @default.
• W2169137344 cites W3112761749 @default.
• W2169137344 cites W3167538985 @default.
• W2169137344 doi "https://doi.org/10.1371/journal.pbio.0050315" @default.
• W2169137344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2229858" @default.
• W2169137344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18044989" @default.
• W2169137344 hasPublicationYear "2007" @default.
• W2169137344 type Work @default.
• W2169137344 sameAs 2169137344 @default.
• W2169137344 citedByCount "130" @default.
• W2169137344 countsByYear W21691373442012 @default.
• W2169137344 countsByYear W21691373442013 @default.
• W2169137344 countsByYear W21691373442014 @default.
• W2169137344 countsByYear W21691373442015 @default.
• W2169137344 countsByYear W21691373442016 @default.
• W2169137344 countsByYear W21691373442017 @default.
• W2169137344 countsByYear W21691373442018 @default.
• W2169137344 countsByYear W21691373442019 @default.
• W2169137344 countsByYear W21691373442020 @default.
• W2169137344 countsByYear W21691373442021 @default.
• W2169137344 countsByYear W21691373442022 @default.
• W2169137344 countsByYear W21691373442023 @default.
• W2169137344 crossrefType "journal-article" @default.
• W2169137344 hasAuthorship W2169137344A5020316144 @default.
• W2169137344 hasAuthorship W2169137344A5021755079 @default.
• W2169137344 hasAuthorship W2169137344A5036989414 @default.
• W2169137344 hasAuthorship W2169137344A5072616070 @default.
• W2169137344 hasAuthorship W2169137344A5085432609 @default.
• W2169137344 hasBestOaLocation W21691373441 @default.
• W2169137344 hasConcept C121332964 @default.
• W2169137344 hasConcept C121446783 @default.
• W2169137344 hasConcept C126322002 @default.
• W2169137344 hasConcept C1276947 @default.
• W2169137344 hasConcept C135343436 @default.
• W2169137344 hasConcept C144543706 @default.
• W2169137344 hasConcept C169760540 @default.
• W2169137344 hasConcept C19720800 @default.
• W2169137344 hasConcept C24890656 @default.
• W2169137344 hasConcept C2776476923 @default.
• W2169137344 hasConcept C2778880379 @default.
• W2169137344 hasConcept C2779027399 @default.
• W2169137344 hasConcept C2781291010 @default.
• W2169137344 hasConcept C38606739 @default.
• W2169137344 hasConcept C59822182 @default.
• W2169137344 hasConcept C71924100 @default.
• W2169137344 hasConcept C86803240 @default.
• W2169137344 hasConcept C95444343 @default.
• W2169137344 hasConceptScore W2169137344C121332964 @default.
• W2169137344 hasConceptScore W2169137344C121446783 @default.
• W2169137344 hasConceptScore W2169137344C126322002 @default.
• W2169137344 hasConceptScore W2169137344C1276947 @default.
• W2169137344 hasConceptScore W2169137344C135343436 @default.
• W2169137344 hasConceptScore W2169137344C144543706 @default.
• W2169137344 hasConceptScore W2169137344C169760540 @default.

• next