FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169143978> ?p ?o ?g. }

• W2169143978 endingPage "416" @default.
• W2169143978 startingPage "410" @default.
• W2169143978 abstract "Background: Despite the importance of oxidative stress and apoptosis through mitochondrial depolarization in neurodegenerative diseases, their roles in etiology of glaucoma are poorly understood. We aimed to investigate whether oxidative stress and apoptosis formation are altered in rat pheochromocytoma-derived cell line-12 (PC12) neuronal cell cultures exposed to elevated different hydrostatic pressures as a cell culture model of glaucoma. Materials: Cultured PC12 cells were subjected to 0, 15 and 70 mmHg hydrostatic pressure for 1 and 24 h. Then, the following values were analyzed: (a) cell viability; (b) lipid peroxidation and intracellular reactive oxygen species production; (c) mitochondrial membrane depolarization; (d) cell apoptosis; (e) caspase-3 and caspase-9 activities; (f) reduced glutathione (GSH) and glutathione peroxidase (GSH-Px). Results: The hydrostatic pressures (15 and 70 mmHg) increased oxidative cell damage through a decrease of GSH and GSH-Px values, and increasing mitochondrial membrane potential. Additionally, 70 mmHg hydrostatic pressure for 24 h indicated highest apoptotic effects, as demonstrated by plate reader analyses of apoptosis, caspase-3 and -9 values. Conclusion: The present data indicated oxidative stress, apoptosis and mitochondrial changes in PC12 cell line during different hydrostatic pressure as a cell culture model of glaucoma. This findings support the view that mitochondrial oxidative injury contributes early to glaucomatous optic neuropathy." @default.
• W2169143978 created "2016-06-24" @default.
• W2169143978 creator A5015317989 @default.
• W2169143978 creator A5028541442 @default.
• W2169143978 creator A5067804693 @default.
• W2169143978 creator A5068857256 @default.
• W2169143978 date "2014-05-08" @default.
• W2169143978 modified "2023-10-12" @default.
• W2169143978 title "Elevated hydrostatic pressures induce apoptosis and oxidative stress through mitochondrial membrane depolarization in PC12 neuronal cells: A cell culture model of glaucoma" @default.
• W2169143978 cites W1775749144 @default.
• W2169143978 cites W1941647560 @default.
• W2169143978 cites W1968779471 @default.
• W2169143978 cites W1968824020 @default.
• W2169143978 cites W1970796115 @default.
• W2169143978 cites W1972678927 @default.
• W2169143978 cites W1973757121 @default.
• W2169143978 cites W1975980695 @default.
• W2169143978 cites W1976811653 @default.
• W2169143978 cites W1977213061 @default.
• W2169143978 cites W1977804812 @default.
• W2169143978 cites W1979172684 @default.
• W2169143978 cites W1991332502 @default.
• W2169143978 cites W1997319312 @default.
• W2169143978 cites W2008746284 @default.
• W2169143978 cites W2010209131 @default.
• W2169143978 cites W2015309205 @default.
• W2169143978 cites W2023773512 @default.
• W2169143978 cites W2027756656 @default.
• W2169143978 cites W2028023737 @default.
• W2169143978 cites W2036329737 @default.
• W2169143978 cites W2043097986 @default.
• W2169143978 cites W2045639157 @default.
• W2169143978 cites W2046045558 @default.
• W2169143978 cites W2053260993 @default.
• W2169143978 cites W2057266151 @default.
• W2169143978 cites W2057818120 @default.
• W2169143978 cites W2063576996 @default.
• W2169143978 cites W2076196604 @default.
• W2169143978 cites W2101169632 @default.
• W2169143978 cites W2102592153 @default.
• W2169143978 cites W2119941231 @default.
• W2169143978 cites W2165220300 @default.
• W2169143978 cites W2189820974 @default.
• W2169143978 cites W2466569869 @default.
• W2169143978 doi "https://doi.org/10.3109/10799893.2014.910812" @default.
• W2169143978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24809391" @default.
• W2169143978 hasPublicationYear "2014" @default.
• W2169143978 type Work @default.
• W2169143978 sameAs 2169143978 @default.
• W2169143978 citedByCount "22" @default.
• W2169143978 countsByYear W21691439782015 @default.
• W2169143978 countsByYear W21691439782016 @default.
• W2169143978 countsByYear W21691439782017 @default.
• W2169143978 countsByYear W21691439782018 @default.
• W2169143978 countsByYear W21691439782019 @default.
• W2169143978 countsByYear W21691439782020 @default.
• W2169143978 countsByYear W21691439782021 @default.
• W2169143978 countsByYear W21691439782022 @default.
• W2169143978 countsByYear W21691439782023 @default.
• W2169143978 crossrefType "journal-article" @default.
• W2169143978 hasAuthorship W2169143978A5015317989 @default.
• W2169143978 hasAuthorship W2169143978A5028541442 @default.
• W2169143978 hasAuthorship W2169143978A5067804693 @default.
• W2169143978 hasAuthorship W2169143978A5068857256 @default.
• W2169143978 hasConcept C121332964 @default.
• W2169143978 hasConcept C134018914 @default.
• W2169143978 hasConcept C181199279 @default.
• W2169143978 hasConcept C185592680 @default.
• W2169143978 hasConcept C190283241 @default.
• W2169143978 hasConcept C2775838275 @default.
• W2169143978 hasConcept C2776151105 @default.
• W2169143978 hasConcept C2778760513 @default.
• W2169143978 hasConcept C2780829032 @default.
• W2169143978 hasConcept C28859421 @default.
• W2169143978 hasConcept C2910081258 @default.
• W2169143978 hasConcept C29311851 @default.
• W2169143978 hasConcept C4141045 @default.
• W2169143978 hasConcept C48349386 @default.
• W2169143978 hasConcept C538909803 @default.
• W2169143978 hasConcept C55493867 @default.
• W2169143978 hasConcept C86803240 @default.
• W2169143978 hasConcept C95444343 @default.
• W2169143978 hasConcept C97355855 @default.
• W2169143978 hasConceptScore W2169143978C121332964 @default.
• W2169143978 hasConceptScore W2169143978C134018914 @default.
• W2169143978 hasConceptScore W2169143978C181199279 @default.
• W2169143978 hasConceptScore W2169143978C185592680 @default.
• W2169143978 hasConceptScore W2169143978C190283241 @default.
• W2169143978 hasConceptScore W2169143978C2775838275 @default.
• W2169143978 hasConceptScore W2169143978C2776151105 @default.
• W2169143978 hasConceptScore W2169143978C2778760513 @default.
• W2169143978 hasConceptScore W2169143978C2780829032 @default.
• W2169143978 hasConceptScore W2169143978C28859421 @default.
• W2169143978 hasConceptScore W2169143978C2910081258 @default.
• W2169143978 hasConceptScore W2169143978C29311851 @default.
• W2169143978 hasConceptScore W2169143978C4141045 @default.
• W2169143978 hasConceptScore W2169143978C48349386 @default.
• W2169143978 hasConceptScore W2169143978C538909803 @default.

• next