FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169144617> ?p ?o ?g. }

• W2169144617 endingPage "2108" @default.
• W2169144617 startingPage "2100" @default.
• W2169144617 abstract "Osteosarcoma is the most common primary malignant bone tumor and affects a significant portion of pediatric oncology patients. Although surgery and adjuvant chemotherapy confer significant survival benefits, many patients go on to develop metastatic disease, particularly to the lungs, secondary to development of drug resistance. Inhibition of protein phosphatase 2A with the small molecule, LB100, has demonstrated potent chemo- and radio-sensitizing properties in numerous pre-clinical tumor models. In this study, we showed that LB100 overcame DNA repair mechanisms in osteosarcoma cells treated with cisplatin, in vitro, and recapitulated these findings in an in vivo xenograft model. Notably, the addition of LB100 to cisplatin prevented development of pulmonary metastases in the majority of treated animals. Our data indicated the mechanism of chemo-sensitization by LB100 involved abrogation of the ATM/ATR-activated DNA damage response, leading to hyperphosphorylation of Chk proteins and persistent cyclin activity. In addition, LB100 exposure suppressed Akt signaling, leading to Mdm2-mediated proteasomal degradation of functional p53. Taken together, LB100 prevented repair of cisplatin-induced DNA damage, resulting in mitotic catastrophe and cell death." @default.
• W2169144617 created "2016-06-24" @default.
• W2169144617 creator A5002456827 @default.
• W2169144617 creator A5014839311 @default.
• W2169144617 creator A5024315850 @default.
• W2169144617 creator A5039390925 @default.
• W2169144617 creator A5039962835 @default.
• W2169144617 creator A5042897178 @default.
• W2169144617 creator A5043148975 @default.
• W2169144617 creator A5047758475 @default.
• W2169144617 creator A5058912128 @default.
• W2169144617 creator A5059419027 @default.
• W2169144617 creator A5083487683 @default.
• W2169144617 creator A5089966579 @default.
• W2169144617 date "2015-06-10" @default.
• W2169144617 modified "2023-09-22" @default.
• W2169144617 title "Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment" @default.
• W2169144617 cites W1529613601 @default.
• W2169144617 cites W1970209924 @default.
• W2169144617 cites W1970680297 @default.
• W2169144617 cites W1985983218 @default.
• W2169144617 cites W1988325237 @default.
• W2169144617 cites W1991327249 @default.
• W2169144617 cites W2011551652 @default.
• W2169144617 cites W2012706949 @default.
• W2169144617 cites W2014305454 @default.
• W2169144617 cites W2027279736 @default.
• W2169144617 cites W2029580240 @default.
• W2169144617 cites W2050060913 @default.
• W2169144617 cites W2053432671 @default.
• W2169144617 cites W2058891255 @default.
• W2169144617 cites W2067829451 @default.
• W2169144617 cites W2070544692 @default.
• W2169144617 cites W2075972167 @default.
• W2169144617 cites W2077536394 @default.
• W2169144617 cites W2087670396 @default.
• W2169144617 cites W2097608507 @default.
• W2169144617 cites W2110054586 @default.
• W2169144617 cites W2126173008 @default.
• W2169144617 cites W2127923895 @default.
• W2169144617 cites W2132653172 @default.
• W2169144617 cites W2149703879 @default.
• W2169144617 cites W2150526285 @default.
• W2169144617 cites W2164196258 @default.
• W2169144617 cites W2166050970 @default.
• W2169144617 cites W2329218644 @default.
• W2169144617 doi "https://doi.org/10.1080/15384101.2015.1041693" @default.
• W2169144617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4612123" @default.
• W2169144617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25942376" @default.
• W2169144617 hasPublicationYear "2015" @default.
• W2169144617 type Work @default.
• W2169144617 sameAs 2169144617 @default.
• W2169144617 citedByCount "19" @default.
• W2169144617 countsByYear W21691446172015 @default.
• W2169144617 countsByYear W21691446172016 @default.
• W2169144617 countsByYear W21691446172017 @default.
• W2169144617 countsByYear W21691446172018 @default.
• W2169144617 countsByYear W21691446172019 @default.
• W2169144617 countsByYear W21691446172021 @default.
• W2169144617 countsByYear W21691446172022 @default.
• W2169144617 crossrefType "journal-article" @default.
• W2169144617 hasAuthorship W2169144617A5002456827 @default.
• W2169144617 hasAuthorship W2169144617A5014839311 @default.
• W2169144617 hasAuthorship W2169144617A5024315850 @default.
• W2169144617 hasAuthorship W2169144617A5039390925 @default.
• W2169144617 hasAuthorship W2169144617A5039962835 @default.
• W2169144617 hasAuthorship W2169144617A5042897178 @default.
• W2169144617 hasAuthorship W2169144617A5043148975 @default.
• W2169144617 hasAuthorship W2169144617A5047758475 @default.
• W2169144617 hasAuthorship W2169144617A5058912128 @default.
• W2169144617 hasAuthorship W2169144617A5059419027 @default.
• W2169144617 hasAuthorship W2169144617A5083487683 @default.
• W2169144617 hasAuthorship W2169144617A5089966579 @default.
• W2169144617 hasBestOaLocation W21691446171 @default.
• W2169144617 hasConcept C105696609 @default.
• W2169144617 hasConcept C11960822 @default.
• W2169144617 hasConcept C120504264 @default.
• W2169144617 hasConcept C134935766 @default.
• W2169144617 hasConcept C143425029 @default.
• W2169144617 hasConcept C150903083 @default.
• W2169144617 hasConcept C178666793 @default.
• W2169144617 hasConcept C186000732 @default.
• W2169144617 hasConcept C190283241 @default.
• W2169144617 hasConcept C207001950 @default.
• W2169144617 hasConcept C2776192174 @default.
• W2169144617 hasConcept C2776694085 @default.
• W2169144617 hasConcept C2777760704 @default.
• W2169144617 hasConcept C2778198054 @default.
• W2169144617 hasConcept C2778239845 @default.
• W2169144617 hasConcept C2778437423 @default.
• W2169144617 hasConcept C29537977 @default.
• W2169144617 hasConcept C389152 @default.
• W2169144617 hasConcept C502942594 @default.
• W2169144617 hasConcept C54355233 @default.
• W2169144617 hasConcept C552990157 @default.
• W2169144617 hasConcept C55493867 @default.
• W2169144617 hasConcept C75217442 @default.
• W2169144617 hasConcept C86803240 @default.

• next