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- W2169165478 abstract "Prediabetes, a high-risk state for future development of diabetes, is prevalent globally. Abnormalities in the incretin axis are important in the progression of B-cell failure in type 2 diabetes. Incretin based therapy was found to improve B cell mass and glycaemic control in addition to having multiple beneficial effects on the systolic and diastolic blood pressure, weight loss in addition to their other beneficial effects on the liver and cardiovascular system. In prediabetes, several well-designed preventive trials have shown that lifestyle and pharmacologic interventions such as metformin, thiazolidinediones (TZD), acarbose and, nateglinide and orlistat, are effective in reducing diabetes development. In recent small studies, incretin based therapy (DPP IV inhibitors and GLP-1 agonists) have also been extended to patients with prediabetes since it was shown to better preserve B-cell function and mass in animal studies and in clinical trials and it was also shown to help maintain good long term metabolic control. Because of the limited studies and clinical experience, their side effects and costs currently guidelines do not recommend incretin-based therapies as an option for treatment in patients with prediabetes. With future clinical trials and studies they may be recommended for patients with impaired fasting glucose or impaired glucose tolerance." @default.
- W2169165478 created "2016-06-24" @default.
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- W2169165478 date "2014-12-01" @default.
- W2169165478 modified "2023-09-23" @default.
- W2169165478 title "The role of incretin-based therapies in prediabetes: A review" @default.
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- W2169165478 cites W1942040918 @default.
- W2169165478 cites W1970638723 @default.
- W2169165478 cites W1974893245 @default.
- W2169165478 cites W1976980904 @default.
- W2169165478 cites W1980925099 @default.
- W2169165478 cites W1983796537 @default.
- W2169165478 cites W1984696632 @default.
- W2169165478 cites W1984740259 @default.
- W2169165478 cites W1985171403 @default.
- W2169165478 cites W1985882361 @default.
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- W2169165478 cites W2000976083 @default.
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- W2169165478 cites W2007910256 @default.
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- W2169165478 cites W2011499650 @default.
- W2169165478 cites W2015495370 @default.
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- W2169165478 doi "https://doi.org/10.1016/j.pcd.2014.02.005" @default.
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