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- W2169177499 abstract "Long-term engraftment following in utero hematopoietic stem cell transplantation (IUHCT) requires the development of T cell tolerance through the deletion of alloreactive T cell clones and anergy in the remaining non-deleted clones. In response to viral illness, however, a dramatic T cell expansion occurs which may include the expansion of anergic alloreactive T cells. Expansion of these subsets could result in an abrupt rejection of previously engrafted donor cells, permitting devastating relapse of disease in the patient. Therefore, we wondered if T cell tolerance is dependent upon the cellular activation state and if engraftment can be maintained during a viral infection. We hypothesized that during the course of viral infection, alloreactive T cell subsets would expand in allogeneic chimeras." @default.
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- W2169177499 date "2013-02-01" @default.
- W2169177499 modified "2023-09-27" @default.
- W2169177499 title "Clonal Deletion of Donor-Reactive T Cell Subsets in Prenatal Allogeneic Chimeras is Preserved During Potent Viral Infection" @default.
- W2169177499 doi "https://doi.org/10.1016/j.jss.2012.10.507" @default.
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