Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169183763> ?p ?o ?g. }
- W2169183763 endingPage "271" @default.
- W2169183763 startingPage "263" @default.
- W2169183763 abstract "The purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy." @default.
- W2169183763 created "2016-06-24" @default.
- W2169183763 creator A5012793137 @default.
- W2169183763 creator A5014639047 @default.
- W2169183763 creator A5020147975 @default.
- W2169183763 creator A5022443428 @default.
- W2169183763 creator A5024971362 @default.
- W2169183763 creator A5043779635 @default.
- W2169183763 creator A5046524695 @default.
- W2169183763 creator A5048837947 @default.
- W2169183763 creator A5063499064 @default.
- W2169183763 creator A5067985868 @default.
- W2169183763 creator A5081888915 @default.
- W2169183763 date "2010-01-01" @default.
- W2169183763 modified "2023-10-02" @default.
- W2169183763 title "Quetiapine Ameliorates Anxiety-Like Behavior and Cognitive Impairments in Stressed Rats: Implications for the Treatment of Posttraumatic Stress Disorder" @default.
- W2169183763 cites W12676479 @default.
- W2169183763 cites W1499701307 @default.
- W2169183763 cites W1509868652 @default.
- W2169183763 cites W1536317835 @default.
- W2169183763 cites W1802655461 @default.
- W2169183763 cites W1972528511 @default.
- W2169183763 cites W1973141367 @default.
- W2169183763 cites W1983858677 @default.
- W2169183763 cites W1988425017 @default.
- W2169183763 cites W1988637086 @default.
- W2169183763 cites W1996447644 @default.
- W2169183763 cites W2003720803 @default.
- W2169183763 cites W2009211323 @default.
- W2169183763 cites W2013549678 @default.
- W2169183763 cites W2018298513 @default.
- W2169183763 cites W2021702442 @default.
- W2169183763 cites W2024340213 @default.
- W2169183763 cites W2024413432 @default.
- W2169183763 cites W2030800922 @default.
- W2169183763 cites W2039047753 @default.
- W2169183763 cites W2039352334 @default.
- W2169183763 cites W2039734777 @default.
- W2169183763 cites W2041806676 @default.
- W2169183763 cites W2046177214 @default.
- W2169183763 cites W2050463389 @default.
- W2169183763 cites W2050831289 @default.
- W2169183763 cites W2051270857 @default.
- W2169183763 cites W2056838287 @default.
- W2169183763 cites W2085712731 @default.
- W2169183763 cites W2088710139 @default.
- W2169183763 cites W2091200572 @default.
- W2169183763 cites W2104860608 @default.
- W2169183763 cites W2112894153 @default.
- W2169183763 cites W2117177930 @default.
- W2169183763 cites W2128738187 @default.
- W2169183763 cites W2133169762 @default.
- W2169183763 cites W2137392968 @default.
- W2169183763 cites W2139565721 @default.
- W2169183763 cites W2153769279 @default.
- W2169183763 cites W2156994072 @default.
- W2169183763 cites W2163815564 @default.
- W2169183763 cites W2164200674 @default.
- W2169183763 cites W2170834410 @default.
- W2169183763 cites W70440412 @default.
- W2169183763 doi "https://doi.org/10.33549/physiolres.931756" @default.
- W2169183763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19537923" @default.
- W2169183763 hasPublicationYear "2010" @default.
- W2169183763 type Work @default.
- W2169183763 sameAs 2169183763 @default.
- W2169183763 citedByCount "40" @default.
- W2169183763 countsByYear W21691837632012 @default.
- W2169183763 countsByYear W21691837632013 @default.
- W2169183763 countsByYear W21691837632014 @default.
- W2169183763 countsByYear W21691837632015 @default.
- W2169183763 countsByYear W21691837632016 @default.
- W2169183763 countsByYear W21691837632018 @default.
- W2169183763 countsByYear W21691837632019 @default.
- W2169183763 countsByYear W21691837632020 @default.
- W2169183763 countsByYear W21691837632022 @default.
- W2169183763 countsByYear W21691837632023 @default.
- W2169183763 crossrefType "journal-article" @default.
- W2169183763 hasAuthorship W2169183763A5012793137 @default.
- W2169183763 hasAuthorship W2169183763A5014639047 @default.
- W2169183763 hasAuthorship W2169183763A5020147975 @default.
- W2169183763 hasAuthorship W2169183763A5022443428 @default.
- W2169183763 hasAuthorship W2169183763A5024971362 @default.
- W2169183763 hasAuthorship W2169183763A5043779635 @default.
- W2169183763 hasAuthorship W2169183763A5046524695 @default.
- W2169183763 hasAuthorship W2169183763A5048837947 @default.
- W2169183763 hasAuthorship W2169183763A5063499064 @default.
- W2169183763 hasAuthorship W2169183763A5067985868 @default.
- W2169183763 hasAuthorship W2169183763A5081888915 @default.
- W2169183763 hasBestOaLocation W21691837631 @default.
- W2169183763 hasConcept C118552586 @default.
- W2169183763 hasConcept C126322002 @default.
- W2169183763 hasConcept C15744967 @default.
- W2169183763 hasConcept C169760540 @default.
- W2169183763 hasConcept C169900460 @default.
- W2169183763 hasConcept C173586616 @default.
- W2169183763 hasConcept C2775858765 @default.
- W2169183763 hasConcept C2776412080 @default.
- W2169183763 hasConcept C2778402161 @default.