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- W2169184428 abstract "Cyclical formation and regression of the ovarian corpus luteum is required for reproduction. During luteal regression, the microvasculature of the corpus luteum is extensively disrupted. Prostaglandin F2α, a primary signal for luteal regression, induces the expression of transforming growth factor β1 (TGFB1) in the corpus luteum. This study determined the actions of TGFB1 on microvascular endothelial cells isolated from the bovine corpus luteum (CLENDO cells). We hypothesized that TGFB1 participates in the disruption of the microvasculature during luteal regression. TGFB1 activated the canonical SMAD signaling pathway in CLENDO cells. TGFB1 (1 ng/ml) significantly reduced both basal and fetal-calf-serum-stimulated DNA synthesis, without reducing cell viability. TGFB1 also significantly reduced CLENDO cell transwell migration and disrupted the formation of capillary-like structures when CLENDO cells were plated on Matrigel. By contrast, CLENDO cells plated on fibrillar collagen I gels did not form capillary-like structures and TGFB1 induced cell death. Additionally, TGFB1 caused loss of VE-cadherin from cellular junctions and loss of cell-cell contacts, and increased the permeability of confluent CLENDO cell monolayers. These studies demonstrate that TGFB1 acts directly on CLENDO cells to limit endothelial cell function and suggest that TGFB1 might act in the disassembly of capillaries observed during luteal regression." @default.
- W2169184428 created "2016-06-24" @default.
- W2169184428 creator A5056477646 @default.
- W2169184428 creator A5059049581 @default.
- W2169184428 date "2011-07-15" @default.
- W2169184428 modified "2023-10-04" @default.
- W2169184428 title "TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum" @default.
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- W2169184428 doi "https://doi.org/10.1242/jcs.084558" @default.
- W2169184428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6518331" @default.
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- W2169184428 hasPublicationYear "2011" @default.
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