Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169184588> ?p ?o ?g. }
- W2169184588 endingPage "970" @default.
- W2169184588 startingPage "961" @default.
- W2169184588 abstract "Osteoporosis is a major health problem; however, the mechanisms regulating adult bone mass are poorly understood. Cas-interacting zinc finger protein (CIZ) is a nucleocytoplasmic shuttling protein that localizes at cell adhesion plaques that form where osteoblasts attach to substrate. To investigate the potential role of CIZ in regulating adult bone mass, we examined the bones in CIZ-deficient mice. Bone volume was increased and the rates of bone formation were increased in CIZ-deficient mice, whereas bone resorption was not altered. CIZ deficiency enhanced the levels of mRNA expression of genes encoding proteins related to osteoblastic phenotypes, such as alkaline phosphatase (ALP) as well as osterix mRNA expression in whole long bones. Bone marrow cells obtained from the femora of CIZ-deficient mice revealed higher ALP activity in culture and formed more mineralized nodules than wild-type cells. CIZ deficiency enhanced bone morphogenetic protein (BMP)-induced osteoblastic differentiation in bone marrow cells in cultures, indicating that BMP is the target of CIZ action. CIZ deficiency increased newly formed bone mass after femoral bone marrow ablation in vivo. Finally, BMP-2-induced bone formation on adult mouse calvariae in vivo was enhanced by CIZ deficiency. These results establish that CIZ suppresses the levels of adult bone mass through inhibition of BMP-induced activation of osteoblasts." @default.
- W2169184588 created "2016-06-24" @default.
- W2169184588 creator A5008935686 @default.
- W2169184588 creator A5028833511 @default.
- W2169184588 creator A5034273023 @default.
- W2169184588 creator A5053188493 @default.
- W2169184588 creator A5055639031 @default.
- W2169184588 creator A5058094492 @default.
- W2169184588 creator A5079064359 @default.
- W2169184588 creator A5081454261 @default.
- W2169184588 creator A5087946840 @default.
- W2169184588 creator A5088372604 @default.
- W2169184588 date "2005-03-21" @default.
- W2169184588 modified "2023-10-18" @default.
- W2169184588 title "The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein–induced bone formation" @default.
- W2169184588 cites W1873184289 @default.
- W2169184588 cites W1965620749 @default.
- W2169184588 cites W1979728988 @default.
- W2169184588 cites W1980337975 @default.
- W2169184588 cites W1986493172 @default.
- W2169184588 cites W1992313364 @default.
- W2169184588 cites W2001084083 @default.
- W2169184588 cites W2012821794 @default.
- W2169184588 cites W2019037276 @default.
- W2169184588 cites W2022635753 @default.
- W2169184588 cites W2028778901 @default.
- W2169184588 cites W2030294841 @default.
- W2169184588 cites W2033904138 @default.
- W2169184588 cites W2046597024 @default.
- W2169184588 cites W2059059445 @default.
- W2169184588 cites W2069807028 @default.
- W2169184588 cites W2080414061 @default.
- W2169184588 cites W2086989005 @default.
- W2169184588 cites W2087378917 @default.
- W2169184588 cites W2106044952 @default.
- W2169184588 cites W2115861809 @default.
- W2169184588 cites W2121903013 @default.
- W2169184588 cites W2127571585 @default.
- W2169184588 cites W2131601689 @default.
- W2169184588 cites W2134812217 @default.
- W2169184588 cites W2149250436 @default.
- W2169184588 cites W2150250172 @default.
- W2169184588 cites W2157090471 @default.
- W2169184588 cites W2157515890 @default.
- W2169184588 cites W2161736514 @default.
- W2169184588 cites W2168609932 @default.
- W2169184588 cites W2171757257 @default.
- W2169184588 cites W2217868403 @default.
- W2169184588 cites W30519312 @default.
- W2169184588 cites W4300174304 @default.
- W2169184588 doi "https://doi.org/10.1084/jem.20041097" @default.
- W2169184588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2213105" @default.
- W2169184588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15781586" @default.
- W2169184588 hasPublicationYear "2005" @default.
- W2169184588 type Work @default.
- W2169184588 sameAs 2169184588 @default.
- W2169184588 citedByCount "66" @default.
- W2169184588 countsByYear W21691845882012 @default.
- W2169184588 countsByYear W21691845882013 @default.
- W2169184588 countsByYear W21691845882014 @default.
- W2169184588 countsByYear W21691845882015 @default.
- W2169184588 countsByYear W21691845882016 @default.
- W2169184588 countsByYear W21691845882017 @default.
- W2169184588 countsByYear W21691845882018 @default.
- W2169184588 countsByYear W21691845882019 @default.
- W2169184588 countsByYear W21691845882020 @default.
- W2169184588 countsByYear W21691845882021 @default.
- W2169184588 countsByYear W21691845882022 @default.
- W2169184588 countsByYear W21691845882023 @default.
- W2169184588 crossrefType "journal-article" @default.
- W2169184588 hasAuthorship W2169184588A5008935686 @default.
- W2169184588 hasAuthorship W2169184588A5028833511 @default.
- W2169184588 hasAuthorship W2169184588A5034273023 @default.
- W2169184588 hasAuthorship W2169184588A5053188493 @default.
- W2169184588 hasAuthorship W2169184588A5055639031 @default.
- W2169184588 hasAuthorship W2169184588A5058094492 @default.
- W2169184588 hasAuthorship W2169184588A5079064359 @default.
- W2169184588 hasAuthorship W2169184588A5081454261 @default.
- W2169184588 hasAuthorship W2169184588A5087946840 @default.
- W2169184588 hasAuthorship W2169184588A5088372604 @default.
- W2169184588 hasBestOaLocation W21691845881 @default.
- W2169184588 hasConcept C104317684 @default.
- W2169184588 hasConcept C126322002 @default.
- W2169184588 hasConcept C134018914 @default.
- W2169184588 hasConcept C185592680 @default.
- W2169184588 hasConcept C202751555 @default.
- W2169184588 hasConcept C203014093 @default.
- W2169184588 hasConcept C2780007613 @default.
- W2169184588 hasConcept C30352789 @default.
- W2169184588 hasConcept C31507581 @default.
- W2169184588 hasConcept C55493867 @default.
- W2169184588 hasConcept C673006 @default.
- W2169184588 hasConcept C71924100 @default.
- W2169184588 hasConcept C86803240 @default.
- W2169184588 hasConcept C95444343 @default.
- W2169184588 hasConceptScore W2169184588C104317684 @default.
- W2169184588 hasConceptScore W2169184588C126322002 @default.
- W2169184588 hasConceptScore W2169184588C134018914 @default.