FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169192103> ?p ?o ?g. }

• W2169192103 endingPage "401" @default.
• W2169192103 startingPage "393" @default.
• W2169192103 abstract "Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN margination by up-regulating expression of adhesion molecules on both PMN and endothelial cells. This study investigated whether substances that modulate TNF synthesis and release influence PMN margination and indomethacin-induced gastric damage.Rats were treated with several doses of indomethacin alone or in association with substances known to increase (interleukin 2 and lipopolysaccharide) or inhibit (pentoxifylline, dexamethasone, granulocyte colony-stimulating factor [G-CSF]) TNF synthesis and release.Indomethacin administration caused dose-dependent damage and increased PMN margination and plasma TNF concentrations. Pretreatment with interleukin 2 and lipopolysaccharide significantly increased TNF release, PMN margination, and gastric mucosal damage, but administration of dexamethasone, pentoxifylline, and G-CSF provided almost total protection. The administration of G-CSF alone caused a significant increase in gastric PMN margination but protected against the indomethacin-induced gastropathy.Agents that regulate TNF synthesis and release influence gastric susceptibility to indomethacin by modulating PMN margination. G-CSF increased PMN infiltration but protected against the mucosal injury, suggesting that PMN margination alone is not sufficient to induce mucosal damage." @default.
• W2169192103 created "2016-06-24" @default.
• W2169192103 creator A5057720130 @default.
• W2169192103 creator A5073371586 @default.
• W2169192103 creator A5074762554 @default.
• W2169192103 creator A5082173292 @default.
• W2169192103 date "1995-02-01" @default.
• W2169192103 modified "2023-10-04" @default.
• W2169192103 title "Role of tumor necrosis factor α release and leukocyte margination in indomethacin-induced gastric injury in rats" @default.
• W2169192103 cites W1514380919 @default.
• W2169192103 cites W1819439991 @default.
• W2169192103 cites W1916146741 @default.
• W2169192103 cites W1988428144 @default.
• W2169192103 cites W2003295582 @default.
• W2169192103 cites W2003902256 @default.
• W2169192103 cites W2024098067 @default.
• W2169192103 cites W2026648244 @default.
• W2169192103 cites W2038434279 @default.
• W2169192103 cites W2049020751 @default.
• W2169192103 cites W2065447230 @default.
• W2169192103 cites W2068858849 @default.
• W2169192103 cites W2092368843 @default.
• W2169192103 cites W2135515147 @default.
• W2169192103 cites W2145739692 @default.
• W2169192103 cites W2151825728 @default.
• W2169192103 cites W2167447755 @default.
• W2169192103 cites W2171870099 @default.
• W2169192103 cites W2176899369 @default.
• W2169192103 cites W2177774817 @default.
• W2169192103 doi "https://doi.org/10.1016/0016-5085(95)90065-9" @default.
• W2169192103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7530670" @default.
• W2169192103 hasPublicationYear "1995" @default.
• W2169192103 type Work @default.
• W2169192103 sameAs 2169192103 @default.
• W2169192103 citedByCount "137" @default.
• W2169192103 countsByYear W21691921032012 @default.
• W2169192103 countsByYear W21691921032013 @default.
• W2169192103 countsByYear W21691921032014 @default.
• W2169192103 countsByYear W21691921032015 @default.
• W2169192103 countsByYear W21691921032016 @default.
• W2169192103 countsByYear W21691921032017 @default.
• W2169192103 countsByYear W21691921032018 @default.
• W2169192103 countsByYear W21691921032019 @default.
• W2169192103 countsByYear W21691921032020 @default.
• W2169192103 countsByYear W21691921032021 @default.
• W2169192103 countsByYear W21691921032023 @default.
• W2169192103 crossrefType "journal-article" @default.
• W2169192103 hasAuthorship W2169192103A5057720130 @default.
• W2169192103 hasAuthorship W2169192103A5073371586 @default.
• W2169192103 hasAuthorship W2169192103A5074762554 @default.
• W2169192103 hasAuthorship W2169192103A5082173292 @default.
• W2169192103 hasConcept C126322002 @default.
• W2169192103 hasConcept C164027704 @default.
• W2169192103 hasConcept C17991360 @default.
• W2169192103 hasConcept C185592680 @default.
• W2169192103 hasConcept C203014093 @default.
• W2169192103 hasConcept C2776914184 @default.
• W2169192103 hasConcept C2777983669 @default.
• W2169192103 hasConcept C2778690821 @default.
• W2169192103 hasConcept C2778754761 @default.
• W2169192103 hasConcept C2780401358 @default.
• W2169192103 hasConcept C2780404050 @default.
• W2169192103 hasConcept C2780942790 @default.
• W2169192103 hasConcept C71924100 @default.
• W2169192103 hasConcept C98274493 @default.
• W2169192103 hasConceptScore W2169192103C126322002 @default.
• W2169192103 hasConceptScore W2169192103C164027704 @default.
• W2169192103 hasConceptScore W2169192103C17991360 @default.
• W2169192103 hasConceptScore W2169192103C185592680 @default.
• W2169192103 hasConceptScore W2169192103C203014093 @default.
• W2169192103 hasConceptScore W2169192103C2776914184 @default.
• W2169192103 hasConceptScore W2169192103C2777983669 @default.
• W2169192103 hasConceptScore W2169192103C2778690821 @default.
• W2169192103 hasConceptScore W2169192103C2778754761 @default.
• W2169192103 hasConceptScore W2169192103C2780401358 @default.
• W2169192103 hasConceptScore W2169192103C2780404050 @default.
• W2169192103 hasConceptScore W2169192103C2780942790 @default.
• W2169192103 hasConceptScore W2169192103C71924100 @default.
• W2169192103 hasConceptScore W2169192103C98274493 @default.
• W2169192103 hasIssue "2" @default.
• W2169192103 hasLocation W21691921031 @default.
• W2169192103 hasLocation W21691921032 @default.
• W2169192103 hasOpenAccess W2169192103 @default.
• W2169192103 hasPrimaryLocation W21691921031 @default.
• W2169192103 hasRelatedWork W1977007895 @default.
• W2169192103 hasRelatedWork W2003295582 @default.
• W2169192103 hasRelatedWork W2006377444 @default.
• W2169192103 hasRelatedWork W2024456541 @default.
• W2169192103 hasRelatedWork W2063834619 @default.
• W2169192103 hasRelatedWork W2065584304 @default.
• W2169192103 hasRelatedWork W2094826411 @default.
• W2169192103 hasRelatedWork W2371609395 @default.
• W2169192103 hasRelatedWork W2421074964 @default.
• W2169192103 hasRelatedWork W249118332 @default.
• W2169192103 hasVolume "108" @default.
• W2169192103 isParatext "false" @default.
• W2169192103 isRetracted "false" @default.
• W2169192103 magId "2169192103" @default.

• next