FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169194629> ?p ?o ?g. }

• W2169194629 abstract "Neutrophil recruitment to sites of injury or infection is essential for host defense, but it needs to be tightly regulated to prevent tissue damage. Phosphoinositide 3-kinase (PI3K), that generates the phosphoinositide PI(3,4,5)P3, is necessary for neutrophil motility in vivo, however, the role of SH2-domain–containing 5-inositol phosphatase (SHIP) enzymes, that hydrolyzes PI(3,4,5)P3 to PI(3,4)P2, is not well understood. Here we show that SHIP phosphatases limit neutrophil motility in live zebrafish. Using real-time imaging of bioprobes specific for PI(3,4,5)P3 and PI(3,4)P2 in neutrophils, we found that PI(3,4,5)P3 and PI(3,4)P2 accumulate at the leading edge while PI(3,4)P2 also localizes to the trailing edge of migrating neutrophils in vivo. Depletion of SHIP phosphatases using morpholinos led to increased neutrophil 3D motility and neutrophil infiltration into wounds. The increase in neutrophil wound recruitment in SHIP morphants was rescued by treatment with low dose PI3Kγ inhibitor, suggesting that SHIP limits neutrophil motility by modulating PI3K signaling. Moreover, overexpression of the SHIP phosphatase domain in neutrophils impaired neutrophil 3D migration. Taken together, our findings suggest that SHIP phosphatases control neutrophil inflammation by limiting neutrophil motility in vivo." @default.
• W2169194629 created "2016-06-24" @default.
• W2169194629 creator A5037833836 @default.
• W2169194629 creator A5048021920 @default.
• W2169194629 creator A5071082106 @default.
• W2169194629 creator A5088439981 @default.
• W2169194629 date "2012-01-01" @default.
• W2169194629 modified "2023-10-14" @default.
• W2169194629 title "The SH2-domain-containing inositol 5-phosphatase (SHIP) limits neutrophil motility and wound recruitment in zebrafish" @default.
• W2169194629 cites W1923909350 @default.
• W2169194629 cites W1984494145 @default.
• W2169194629 cites W1987031444 @default.
• W2169194629 cites W1987252087 @default.
• W2169194629 cites W1994262781 @default.
• W2169194629 cites W1995984781 @default.
• W2169194629 cites W2000916443 @default.
• W2169194629 cites W2002054992 @default.
• W2169194629 cites W2002127663 @default.
• W2169194629 cites W2004266914 @default.
• W2169194629 cites W2014172202 @default.
• W2169194629 cites W2024765629 @default.
• W2169194629 cites W2035538295 @default.
• W2169194629 cites W2040813747 @default.
• W2169194629 cites W2042629891 @default.
• W2169194629 cites W2055996292 @default.
• W2169194629 cites W2067585177 @default.
• W2169194629 cites W2068894688 @default.
• W2169194629 cites W2069463594 @default.
• W2169194629 cites W2072805330 @default.
• W2169194629 cites W2077024843 @default.
• W2169194629 cites W2077351642 @default.
• W2169194629 cites W2096542385 @default.
• W2169194629 cites W2099548299 @default.
• W2169194629 cites W2101689648 @default.
• W2169194629 cites W2107425729 @default.
• W2169194629 cites W2124937806 @default.
• W2169194629 cites W2127566892 @default.
• W2169194629 cites W2130443751 @default.
• W2169194629 cites W2134295150 @default.
• W2169194629 cites W2134591087 @default.
• W2169194629 cites W2151313755 @default.
• W2169194629 cites W2151519283 @default.
• W2169194629 cites W2157146227 @default.
• W2169194629 cites W2162332365 @default.
• W2169194629 cites W2162767010 @default.
• W2169194629 cites W2162800505 @default.
• W2169194629 cites W2168407987 @default.
• W2169194629 cites W2168537132 @default.
• W2169194629 cites W2398276155 @default.
• W2169194629 cites W4241058123 @default.
• W2169194629 cites W4243304802 @default.
• W2169194629 doi "https://doi.org/10.1242/jcs.106625" @default.
• W2169194629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3533387" @default.
• W2169194629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22946052" @default.
• W2169194629 hasPublicationYear "2012" @default.
• W2169194629 type Work @default.
• W2169194629 sameAs 2169194629 @default.
• W2169194629 citedByCount "46" @default.
• W2169194629 countsByYear W21691946292013 @default.
• W2169194629 countsByYear W21691946292014 @default.
• W2169194629 countsByYear W21691946292015 @default.
• W2169194629 countsByYear W21691946292016 @default.
• W2169194629 countsByYear W21691946292017 @default.
• W2169194629 countsByYear W21691946292018 @default.
• W2169194629 countsByYear W21691946292019 @default.
• W2169194629 countsByYear W21691946292020 @default.
• W2169194629 countsByYear W21691946292021 @default.
• W2169194629 countsByYear W21691946292022 @default.
• W2169194629 countsByYear W21691946292023 @default.
• W2169194629 crossrefType "journal-article" @default.
• W2169194629 hasAuthorship W2169194629A5037833836 @default.
• W2169194629 hasAuthorship W2169194629A5048021920 @default.
• W2169194629 hasAuthorship W2169194629A5071082106 @default.
• W2169194629 hasAuthorship W2169194629A5088439981 @default.
• W2169194629 hasBestOaLocation W21691946291 @default.
• W2169194629 hasConcept C104317684 @default.
• W2169194629 hasConcept C11960822 @default.
• W2169194629 hasConcept C136449434 @default.
• W2169194629 hasConcept C150903083 @default.
• W2169194629 hasConcept C170493617 @default.
• W2169194629 hasConcept C178666793 @default.
• W2169194629 hasConcept C203014093 @default.
• W2169194629 hasConcept C207001950 @default.
• W2169194629 hasConcept C2776878037 @default.
• W2169194629 hasConcept C54166955 @default.
• W2169194629 hasConcept C55493867 @default.
• W2169194629 hasConcept C58207958 @default.
• W2169194629 hasConcept C62478195 @default.
• W2169194629 hasConcept C86554907 @default.
• W2169194629 hasConcept C86803240 @default.
• W2169194629 hasConcept C8891405 @default.
• W2169194629 hasConcept C95444343 @default.
• W2169194629 hasConceptScore W2169194629C104317684 @default.
• W2169194629 hasConceptScore W2169194629C11960822 @default.
• W2169194629 hasConceptScore W2169194629C136449434 @default.
• W2169194629 hasConceptScore W2169194629C150903083 @default.
• W2169194629 hasConceptScore W2169194629C170493617 @default.
• W2169194629 hasConceptScore W2169194629C178666793 @default.
• W2169194629 hasConceptScore W2169194629C203014093 @default.
• W2169194629 hasConceptScore W2169194629C207001950 @default.

• next