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- W2169197895 abstract "Programmed cell death (PCD) probably plays a critical role in the clinical behavior of human neuroblastomas. This tumor has the highest propensity for spontaneous regression, and there is evidence that this regression may be the consequence of apoptosis induced by neurotrophin deprivation. Indeed, several ligand-receptor pathways have been identified that appear to be important in regulating neuronal survival or cell death. Furthermore, analysis of gene expression in neuroblastomas suggests that the bcl-2 family genes and the caspases may also play important roles in regulating neuronal survival. Finally, like many tumors, apoptosis may be a common pathway of cell death in response to chemotherapeutic agents. Therapeutic approaches aimed at selectively activating PCD in neuroblastomas are under development, and may lead to a more effective and less toxic approach to the treatment." @default.
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- W2169197895 date "1999-01-01" @default.
- W2169197895 modified "2023-09-24" @default.
- W2169197895 title "Role of Apoptosis in Human Neuroblastomas" @default.
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- W2169197895 doi "https://doi.org/10.1007/978-1-59259-720-8_20" @default.
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