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- W2169199787 abstract "Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway that recognizes and degrades aberrant mRNAs containing premature stop codons. A critical protein in NMD is Upf1p, which belongs to the helicase super family 1 (SF1), and is thought to utilize the energy of ATP hydrolysis to promote transitions in the structure of RNA or RNA-protein complexes. The crystal structure of the catalytic core of human Upf1p determined in three states (phosphate-, AMPPNP- and ADP-bound forms) reveals an overall structure containing two RecA-like domains with two additional domains protruding from the N-terminal RecA-like domain. Structural comparison combined with mutational analysis identifies a likely single-stranded RNA (ssRNA)-binding channel, and a cycle of conformational change coupled to ATP binding and hydrolysis. These conformational changes alter the likely ssRNA-binding channel in a manner that can explain how ATP binding destabilizes ssRNA binding to Upf1p." @default.
- W2169199787 created "2016-06-24" @default.
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- W2169199787 date "2006-12-07" @default.
- W2169199787 modified "2023-10-10" @default.
- W2169199787 title "Structural and functional insights into the human Upf1 helicase core" @default.
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- W2169199787 doi "https://doi.org/10.1038/sj.emboj.7601464" @default.
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