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• W2169201856 endingPage "2050" @default.
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• W2169201856 abstract "Pancreatic cancer is one of the deadliest of cancers. Even with aggressive therapy, the 5-year survival rate is <5%, mandating development of more effective treatments. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) shows potent antitumor activity against most cancers displaying safety with significant clinical efficacy. However, pancreatic cancer cells display inherent resistance to mda-7/IL-24 that is the result of a protein translational block of mda-7/IL-24 mRNA in these tumor cells. We now show that a dietary supplement perillyl alcohol (POH) has significant chemopreventive effects for pancreatic cancer and, when coupled with adenovirus-mediated mda-7/IL-24 gene therapy (Ad.mda-7), effectively eliminates s.c. and i.p. xenografts of human pancreatic cancer cells in nude mice, promoting enhanced survival. The combination of POH and Ad.mda-7 efficiently abrogates the mda-7/IL-24 protein translational block, resulting in MDA-7/IL-24 protein production and growth suppression. Of direct translational relevance, clinically achievable concentrations of POH with Ad.mda-7, both of which have been found safe and without toxic effects in human trials, were used. This novel and innovative approach combining a dietary agent and a virally delivered therapeutic cytokine provides a means of both preventing and treating human pancreatic cancer with significant clinical translational potential." @default.
• W2169201856 created "2016-06-24" @default.
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• W2169201856 date "2008-07-01" @default.
• W2169201856 modified "2023-10-05" @default.
• W2169201856 title "Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis" @default.
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• W2169201856 doi "https://doi.org/10.1158/1535-7163.mct-08-0245" @default.
• W2169201856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18645014" @default.
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