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- W2169202852 abstract "We have characterized how perturbations of normal synaptic activity influence the morphology of cholinergic SAB motor neurons that innervate head muscle in C. elegans. Mutations disrupting components of the presynaptic release apparatus, acetylcholine (ACh) synthesis or ACh loading into synaptic vesicles each induced sprouting of SAB axonal processes. These sprouts usually arose in the middle of the normal innervation zone and terminated with a single presynaptic varicosity. Sprouting SAB neurons with a similar morphology were also observed upon reducing activity in muscle, either by using mutants lacking a functional nicotinic ACh receptor subunit or through muscle-specific expression of a gain-of-function potassium channel. Analysis of temperature-sensitive mutants in the choline acetyltransferase gene revealed that the sprouting response to inactivity was developmentally regulated; reduction of synaptic activity in early larval stages, but not in late larval stages, induced both sprouting and addition of varicosities. Our results indicate that activity levels regulate the structure of certain synaptic connections between nerve and muscle in C. elegans. One component of this regulatory machinery is a retrograde signal from the postsynaptic cell that mediates the formation of synaptic connections." @default.
- W2169202852 created "2016-06-24" @default.
- W2169202852 creator A5020846782 @default.
- W2169202852 creator A5022356999 @default.
- W2169202852 date "2000-03-15" @default.
- W2169202852 modified "2023-10-15" @default.
- W2169202852 title "A retrograde signal is involved in activity-dependent remodeling at a <i>C. elegans</i> neuromuscular junction" @default.
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- W2169202852 doi "https://doi.org/10.1242/dev.127.6.1253" @default.
- W2169202852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10683178" @default.
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