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- W2169205901 abstract "The Arabidopsis root has a unique cellular pattern in its single-layered epidermis. Cells residing over the intercellular spaces between underlying cortical cells (H position) differentiate into hair cells, whereas those directly over cortical cells (N position) differentiate into non-hair cells. Recent studies have revealed that this cellular pattern is determined by interactions of six patterning genes CPC , ETC , GL2 , GL3 / EGL3 , TTG , and WER , and that the position-dependent expression of the CPC , GL2 , and WER genes is essential for their appropriate interactions. However, little is known about how the expressions of the pattern genes are determined. Here we show that trichostatin A (TSA) treatment of germinating Arabidopsis seedlings alters the cellular pattern of the root epidermis to induce hair cell development at nonhair positions. The effects of TSA treatment are rapid, reversible, concentration-dependent, and position-independent. TSA inhibition of histone deacetylase activity results in hyperacetylation of the core histones H3 and H4, and alters the expression levels and cell specific expression of the patterning genes CPC , GL2 and WER . Analysis of histone deacetylase mutant cellular patterning further verified the participation of histone acetylation in cellular patterning, and revealed that HDA18 is a key component in the regulatory machinery of the Arabidopsis root epidermis. We propose a working model to suggest that histone acetylation may function in mediating a positional cue to direct expression of the patterning genes in the root epidermal cells." @default.
- W2169205901 created "2016-06-24" @default.
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- W2169205901 date "2005-09-21" @default.
- W2169205901 modified "2023-10-10" @default.
- W2169205901 title "Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis" @default.
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- W2169205901 doi "https://doi.org/10.1073/pnas.0503143102" @default.
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