Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169210630> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2169210630 endingPage "340" @default.
- W2169210630 startingPage "335" @default.
- W2169210630 abstract "Disodium 3β,21-dihydroxypregn-5-en-20-one disulfate (2), sodium 3β,21-dihydroxypregn-5-en-20-one 3-sulfate (3), sodium 3β,21-dihydroxypregn-5-en-20-one 21-sulfate (4), and disodium 3β,6α-dihydroxy-5α-pregnan-20-one disulfate (6) have been synthesized and completely characterized for the first time from readily available materials. Sulfation was performed using triethylamine-sulfur trioxide complex in dimethylformamide as the sulfating agent. Selective sulfation of 3β,21-dihydroxypregn-5-en-20-one rendered sodium 3β,21-dihydroxypregn-5-en-20-one 3-sulfate (3) as the major compound. The synthetic sulfated steroids as well as natural disulfated polyhydroxysteroids (7–9) isolated by us from the antarctic ophiuroid Astrotoma agassizii and the synthetic derivatives disodium 2β,3α,21-trihydroxy-(20R)-cholesta-5,24-diene 3-acetate, 2,21-disulfate (7a) and 2β,3α,21-trihydroxy-(20R)-cholesta-5,24-diene (7b) were comparatively evaluated for their inhibitory effect on the replication of one DNA (HSV-2) and two RNA (PV-3, JV) viruses. In general, steroids with sulfate groups at C-21 and C-2 or C-3 were the most effective in their inhibitory action against HSV-2 and also proved to be active against PV-3 and JV." @default.
- W2169210630 created "2016-06-24" @default.
- W2169210630 creator A5002217816 @default.
- W2169210630 creator A5033847633 @default.
- W2169210630 creator A5063856343 @default.
- W2169210630 creator A5068605061 @default.
- W2169210630 creator A5091465321 @default.
- W2169210630 date "1999-05-01" @default.
- W2169210630 modified "2023-10-10" @default.
- W2169210630 title "Evaluation of the antiviral activity of natural sulfated polyhydroxysteroids and their synthetic derivatives and analogs" @default.
- W2169210630 cites W1821704319 @default.
- W2169210630 cites W1973376056 @default.
- W2169210630 cites W1976660354 @default.
- W2169210630 cites W1983185021 @default.
- W2169210630 cites W1984443850 @default.
- W2169210630 cites W1987533046 @default.
- W2169210630 cites W2012467269 @default.
- W2169210630 cites W2060331766 @default.
- W2169210630 cites W2081800171 @default.
- W2169210630 cites W2092027550 @default.
- W2169210630 cites W2951855235 @default.
- W2169210630 cites W4254119273 @default.
- W2169210630 doi "https://doi.org/10.1016/s0039-128x(99)00016-1" @default.
- W2169210630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10406483" @default.
- W2169210630 hasPublicationYear "1999" @default.
- W2169210630 type Work @default.
- W2169210630 sameAs 2169210630 @default.
- W2169210630 citedByCount "47" @default.
- W2169210630 countsByYear W21692106302013 @default.
- W2169210630 countsByYear W21692106302014 @default.
- W2169210630 countsByYear W21692106302015 @default.
- W2169210630 countsByYear W21692106302016 @default.
- W2169210630 countsByYear W21692106302017 @default.
- W2169210630 countsByYear W21692106302018 @default.
- W2169210630 countsByYear W21692106302019 @default.
- W2169210630 countsByYear W21692106302020 @default.
- W2169210630 countsByYear W21692106302021 @default.
- W2169210630 countsByYear W21692106302022 @default.
- W2169210630 crossrefType "journal-article" @default.
- W2169210630 hasAuthorship W2169210630A5002217816 @default.
- W2169210630 hasAuthorship W2169210630A5033847633 @default.
- W2169210630 hasAuthorship W2169210630A5063856343 @default.
- W2169210630 hasAuthorship W2169210630A5068605061 @default.
- W2169210630 hasAuthorship W2169210630A5091465321 @default.
- W2169210630 hasConcept C155138218 @default.
- W2169210630 hasConcept C178790620 @default.
- W2169210630 hasConcept C185592680 @default.
- W2169210630 hasConcept C2777505907 @default.
- W2169210630 hasConcept C2777712214 @default.
- W2169210630 hasConcept C2778343803 @default.
- W2169210630 hasConcept C2780471494 @default.
- W2169210630 hasConcept C2781283055 @default.
- W2169210630 hasConcept C518881349 @default.
- W2169210630 hasConcept C537181965 @default.
- W2169210630 hasConcept C55493867 @default.
- W2169210630 hasConcept C71240020 @default.
- W2169210630 hasConceptScore W2169210630C155138218 @default.
- W2169210630 hasConceptScore W2169210630C178790620 @default.
- W2169210630 hasConceptScore W2169210630C185592680 @default.
- W2169210630 hasConceptScore W2169210630C2777505907 @default.
- W2169210630 hasConceptScore W2169210630C2777712214 @default.
- W2169210630 hasConceptScore W2169210630C2778343803 @default.
- W2169210630 hasConceptScore W2169210630C2780471494 @default.
- W2169210630 hasConceptScore W2169210630C2781283055 @default.
- W2169210630 hasConceptScore W2169210630C518881349 @default.
- W2169210630 hasConceptScore W2169210630C537181965 @default.
- W2169210630 hasConceptScore W2169210630C55493867 @default.
- W2169210630 hasConceptScore W2169210630C71240020 @default.
- W2169210630 hasIssue "5" @default.
- W2169210630 hasLocation W21692106301 @default.
- W2169210630 hasLocation W21692106302 @default.
- W2169210630 hasOpenAccess W2169210630 @default.
- W2169210630 hasPrimaryLocation W21692106301 @default.
- W2169210630 hasRelatedWork W1892500229 @default.
- W2169210630 hasRelatedWork W1977368384 @default.
- W2169210630 hasRelatedWork W2027036042 @default.
- W2169210630 hasRelatedWork W2044037306 @default.
- W2169210630 hasRelatedWork W2084660029 @default.
- W2169210630 hasRelatedWork W2090918503 @default.
- W2169210630 hasRelatedWork W2528461235 @default.
- W2169210630 hasRelatedWork W2905128512 @default.
- W2169210630 hasRelatedWork W3199577712 @default.
- W2169210630 hasRelatedWork W4225388239 @default.
- W2169210630 hasVolume "64" @default.
- W2169210630 isParatext "false" @default.
- W2169210630 isRetracted "false" @default.
- W2169210630 magId "2169210630" @default.
- W2169210630 workType "article" @default.