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• W2169221312 endingPage "5386" @default.
• W2169221312 startingPage "5374" @default.
• W2169221312 abstract "We examined the effects of somatostatin (SST) on neurons in the thalamic reticular nucleus (RT) using whole-cell patch-clamp techniques applied to visualized neurons in rat thalamic slices. SST, acting via sst₅ receptors and pertussis toxin-sensitive G-proteins, activated an inwardly rectifying K⁺ (GIRK) current in 20 of 28 recorded cells to increase input conductance 15 ± 3% above control and inhibited N-type Ca²⁺ currents in 17 of 24 neurons via voltage-dependent mechanisms. SST reversibly depressed evoked EPSCs (eEPSCs) to 37 ± 8% of control without altering their kinetics. SST-mediated inhibition of eEPSCs showed short-term relief from block during 25 Hz stimulus trains. SST also reduced the frequency (33 ± 8%) but not the amplitude of miniature EPSCs (mEPSCs). These data indicate that SST mediates presynaptic inhibition of glutamate release onto RT neurons. In current-clamp recordings, SST preferentially inhibited burst discharges mediated by near-threshold corticothalamic EPSPs and intracellularly applied depolarizing currents. SST had powerful effects on <i>in vitro</i> intrathalamic rhythms, which included a shortening of the duration and a reduction in spike count within each oscillatory event. Furthermore, there was a paradoxical increase in the synchrony of epileptiform oscillations, likely mediated by a suppression of the responses to weak synaptic inputs in RT. We conclude that SST suppresses discharges in RT neurons, via presynaptic inhibition of glutamate release and postsynaptic activation of GIRK channels, leading to the dampening of both spindle-like and epileptiform thalamic network oscillations. SST may act as an important endogenous regulator of physiological and pathological thalamocortical network activities." @default.
• W2169221312 created "2016-06-24" @default.
• W2169221312 creator A5033400284 @default.
• W2169221312 creator A5082613410 @default.
• W2169221312 creator A5087686008 @default.
• W2169221312 date "2002-07-01" @default.
• W2169221312 modified "2023-10-16" @default.
• W2169221312 title "Somatostatin Inhibits Thalamic Network Oscillations<i>In Vitro</i>: Actions on the GABAergic Neurons of the Reticular Nucleus" @default.
• W2169221312 cites W1485449003 @default.
• W2169221312 cites W1518098954 @default.
• W2169221312 cites W1586263106 @default.
• W2169221312 cites W1598669426 @default.
• W2169221312 cites W1600423268 @default.
• W2169221312 cites W1654673127 @default.
• W2169221312 cites W1752318600 @default.
• W2169221312 cites W1852928000 @default.
• W2169221312 cites W1858600841 @default.
• W2169221312 cites W1898373063 @default.
• W2169221312 cites W1910267240 @default.
• W2169221312 cites W1916197612 @default.
• W2169221312 cites W1935940023 @default.
• W2169221312 cites W1962046274 @default.
• W2169221312 cites W1970041260 @default.
• W2169221312 cites W1971017555 @default.
• W2169221312 cites W1972268296 @default.
• W2169221312 cites W1975893722 @default.
• W2169221312 cites W1980325410 @default.
• W2169221312 cites W1984800507 @default.
• W2169221312 cites W1996892917 @default.
• W2169221312 cites W1999772524 @default.
• W2169221312 cites W2001418258 @default.
• W2169221312 cites W2002189290 @default.
• W2169221312 cites W2003523284 @default.
• W2169221312 cites W2006355149 @default.
• W2169221312 cites W2006965687 @default.
• W2169221312 cites W2007393214 @default.
• W2169221312 cites W2008620248 @default.
• W2169221312 cites W2010337149 @default.
• W2169221312 cites W2010703529 @default.
• W2169221312 cites W2019647856 @default.
• W2169221312 cites W2020911593 @default.
• W2169221312 cites W2024568818 @default.
• W2169221312 cites W2034382807 @default.
• W2169221312 cites W2034912445 @default.
• W2169221312 cites W2035187847 @default.
• W2169221312 cites W2040993125 @default.
• W2169221312 cites W2041157953 @default.
• W2169221312 cites W2041538618 @default.
• W2169221312 cites W2043279327 @default.
• W2169221312 cites W2044937225 @default.
• W2169221312 cites W2059658339 @default.
• W2169221312 cites W2060208580 @default.
• W2169221312 cites W2064748241 @default.
• W2169221312 cites W2066015662 @default.
• W2169221312 cites W2067267876 @default.
• W2169221312 cites W2067699039 @default.
• W2169221312 cites W2068027610 @default.
• W2169221312 cites W2070283619 @default.
• W2169221312 cites W2070993564 @default.
• W2169221312 cites W2071127897 @default.
• W2169221312 cites W2075412186 @default.
• W2169221312 cites W2078516477 @default.
• W2169221312 cites W2097637304 @default.
• W2169221312 cites W2101521576 @default.
• W2169221312 cites W2109746889 @default.
• W2169221312 cites W2110585018 @default.
• W2169221312 cites W2112573636 @default.
• W2169221312 cites W2113945079 @default.
• W2169221312 cites W2116190393 @default.
• W2169221312 cites W2121584771 @default.
• W2169221312 cites W2123988448 @default.
• W2169221312 cites W2124025293 @default.
• W2169221312 cites W2127660458 @default.
• W2169221312 cites W2129933607 @default.
• W2169221312 cites W2131690895 @default.
• W2169221312 cites W2131853244 @default.
• W2169221312 cites W2145321763 @default.
• W2169221312 cites W2152857905 @default.
• W2169221312 cites W2159432306 @default.
• W2169221312 cites W2161137064 @default.
• W2169221312 cites W2163660989 @default.
• W2169221312 cites W2165892338 @default.
• W2169221312 cites W2170897236 @default.
• W2169221312 cites W2170912183 @default.
• W2169221312 cites W2171563174 @default.
• W2169221312 cites W2259951510 @default.
• W2169221312 cites W2260572452 @default.
• W2169221312 cites W2282039127 @default.
• W2169221312 cites W1975198856 @default.
• W2169221312 doi "https://doi.org/10.1523/jneurosci.22-13-05374.2002" @default.
• W2169221312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6758225" @default.
• W2169221312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12097489" @default.
• W2169221312 hasPublicationYear "2002" @default.
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