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• W2169222757 endingPage "7424" @default.
• W2169222757 startingPage "7415" @default.
• W2169222757 abstract "The transcriptional activator Ime1 is a key regulator of meiosis and sporulation in budding yeast. Ime1 is controlled at different levels by nutrients and cell-type signals. Previously, we have proposed that G1 cyclins would transmit nutritional signals to the Ime1 pathway by preventing the accumulation of Ime1 within the nucleus. We show here that nutritional signals regulate the subcellular localization of Ime1 through the TOR pathway. The inactivation of TOR with rapamycin promotes the nuclear accumulation and stabilization of Ime1, with consequent induction of early meiotic genes. On the contrary, the activation of TOR by glutamine induces the relocalization of Ime1 to the cytoplasm. Thus, TOR may sense optimal nitrogen- and carbon-limiting conditions to modulate Ime1 function. Besides TOR, ammonia induces an independent mechanism that prevents the accumulation of Ime1 in the nucleus. Both TOR and ammonia regulate Ime1 localization in the absence of Cdk1 activity and therefore use mechanisms different from those exerted by G1 cyclins. Integration of independent mechanisms into a single early controlling step, such as the nuclear accumulation of Ime1, may help explain why yeast cells execute the meiotic program only when the appropriate internal and external conditions are met together." @default.
• W2169222757 created "2016-06-24" @default.
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• W2169222757 date "2003-10-01" @default.
• W2169222757 modified "2023-10-09" @default.
• W2169222757 title "TOR Regulates the Subcellular Localization of Ime1, a Transcriptional Activator of Meiotic Development in Budding Yeast" @default.
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• W2169222757 doi "https://doi.org/10.1128/mcb.23.20.7415-7424.2003" @default.
• W2169222757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/230322" @default.
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