Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169232707> ?p ?o ?g. }
- W2169232707 endingPage "502" @default.
- W2169232707 startingPage "495" @default.
- W2169232707 abstract "Lactoferrin, a member of the transferrin family of approximately 80 kDa, consists of a single polypeptide chain folded in two symmetric, globular lobes (N- and C-lobes), each able to bind one ferric ion. This glycoprotein, found in physiological fluids of mammals, plays an important role in immune regulation and in defense mechanisms against bacteria, fungi, parasites, and viruses. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. We have investigated both the role of tryptic fragments of bovine lactoferrin and the mechanism of lactoferrin antiviral effect toward adenovirus infection in HEp-2 cells. The results obtained demonstrated that the anti-adenovirus activity of lactoferrin is mediated by the N-terminal half of the protein as the N-lobe was able to inhibit adenovirus infection, even if at lower extent than undigested lactoferrin, whereas C-lobe was ineffective. The results also showed that the anti-adenovirus action of lactoferrin and of its N-terminal peptide lactoferricin took place on virus attachment to cell membrane, mainly through competition for common glycosaminoglycan receptors. The data provide evidence that the anti-adenovirus activity of lactoferrin is mediated mainly by the cluster of positive charges at the N-terminus of whole molecule and that the N-terminal peptide lactoferricin alone is sufficient to prevent infection." @default.
- W2169232707 created "2016-06-24" @default.
- W2169232707 creator A5035317186 @default.
- W2169232707 creator A5037115420 @default.
- W2169232707 creator A5038160331 @default.
- W2169232707 creator A5043187545 @default.
- W2169232707 creator A5066526290 @default.
- W2169232707 creator A5069867687 @default.
- W2169232707 creator A5087332559 @default.
- W2169232707 creator A5087504067 @default.
- W2169232707 date "2003-02-24" @default.
- W2169232707 modified "2023-10-09" @default.
- W2169232707 title "Heparin-interacting sites of bovine lactoferrin are involved in anti-adenovirus activity" @default.
- W2169232707 cites W1488162644 @default.
- W2169232707 cites W1512267378 @default.
- W2169232707 cites W1927596245 @default.
- W2169232707 cites W1930144865 @default.
- W2169232707 cites W1963584900 @default.
- W2169232707 cites W1965473478 @default.
- W2169232707 cites W1970226093 @default.
- W2169232707 cites W1970624286 @default.
- W2169232707 cites W1971800897 @default.
- W2169232707 cites W1973939236 @default.
- W2169232707 cites W1973946974 @default.
- W2169232707 cites W1977139300 @default.
- W2169232707 cites W1977353996 @default.
- W2169232707 cites W1979855883 @default.
- W2169232707 cites W1981996048 @default.
- W2169232707 cites W1985572342 @default.
- W2169232707 cites W1989369582 @default.
- W2169232707 cites W1997357193 @default.
- W2169232707 cites W1999193936 @default.
- W2169232707 cites W2003435597 @default.
- W2169232707 cites W2003915950 @default.
- W2169232707 cites W2021350307 @default.
- W2169232707 cites W2027981940 @default.
- W2169232707 cites W2030509881 @default.
- W2169232707 cites W2033546588 @default.
- W2169232707 cites W2034571940 @default.
- W2169232707 cites W2040310992 @default.
- W2169232707 cites W2049828708 @default.
- W2169232707 cites W2052199417 @default.
- W2169232707 cites W2058175369 @default.
- W2169232707 cites W2059657325 @default.
- W2169232707 cites W2063184873 @default.
- W2169232707 cites W2064749319 @default.
- W2169232707 cites W2066859499 @default.
- W2169232707 cites W2069462791 @default.
- W2169232707 cites W2073027664 @default.
- W2169232707 cites W2082137424 @default.
- W2169232707 cites W2085338361 @default.
- W2169232707 cites W2088050412 @default.
- W2169232707 cites W2089315044 @default.
- W2169232707 cites W2092149961 @default.
- W2169232707 cites W2095870354 @default.
- W2169232707 cites W2106772897 @default.
- W2169232707 cites W2115808507 @default.
- W2169232707 cites W2117094435 @default.
- W2169232707 cites W2119900141 @default.
- W2169232707 cites W2121218869 @default.
- W2169232707 cites W2133603659 @default.
- W2169232707 cites W2151860739 @default.
- W2169232707 cites W2153112402 @default.
- W2169232707 cites W2158124451 @default.
- W2169232707 cites W2163682706 @default.
- W2169232707 cites W2164685578 @default.
- W2169232707 cites W2169019898 @default.
- W2169232707 cites W2170792377 @default.
- W2169232707 cites W2171070492 @default.
- W2169232707 cites W2323347146 @default.
- W2169232707 cites W350270460 @default.
- W2169232707 cites W90346617 @default.
- W2169232707 cites W99360533 @default.
- W2169232707 doi "https://doi.org/10.1002/jmv.10337" @default.
- W2169232707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12601757" @default.
- W2169232707 hasPublicationYear "2003" @default.
- W2169232707 type Work @default.
- W2169232707 sameAs 2169232707 @default.
- W2169232707 citedByCount "67" @default.
- W2169232707 countsByYear W21692327072012 @default.
- W2169232707 countsByYear W21692327072013 @default.
- W2169232707 countsByYear W21692327072014 @default.
- W2169232707 countsByYear W21692327072019 @default.
- W2169232707 countsByYear W21692327072020 @default.
- W2169232707 countsByYear W21692327072021 @default.
- W2169232707 countsByYear W21692327072022 @default.
- W2169232707 countsByYear W21692327072023 @default.
- W2169232707 crossrefType "journal-article" @default.
- W2169232707 hasAuthorship W2169232707A5035317186 @default.
- W2169232707 hasAuthorship W2169232707A5037115420 @default.
- W2169232707 hasAuthorship W2169232707A5038160331 @default.
- W2169232707 hasAuthorship W2169232707A5043187545 @default.
- W2169232707 hasAuthorship W2169232707A5066526290 @default.
- W2169232707 hasAuthorship W2169232707A5069867687 @default.
- W2169232707 hasAuthorship W2169232707A5087332559 @default.
- W2169232707 hasAuthorship W2169232707A5087504067 @default.
- W2169232707 hasConcept C108625454 @default.
- W2169232707 hasConcept C159047783 @default.