Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169235461> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2169235461 endingPage "28" @default.
- W2169235461 startingPage "24" @default.
- W2169235461 abstract "Endotoxin (LPS) was quantitated in experimental subjects and in horses with naturally occurring gastrointestinal strangulation obstruction and/or septicaemic diseases to establish the fate of LPS and the clinical usefulness of the Limulus amoebocyte lysate (LAL) assay. The assay was validated for sensitivity (10 pg/ml), recovery (90 to 106 per cent), intra-assay precision (CV = 5.5 per cent) inter-assay precision (CV = 11 per cent), and stability of diluted, heat treated, frozen samples (at least 90 days). Plasma concentrations of LPS after sublethal (3 μg/kg) jugular or portal vein bolus injections of LPS rose to 4000 pg/ml and 1500 pg/ml respectively followed by a rapid phase of clearance. Peak plasma concentrations of LPS, associated with slow portal infusion, were lower than peak values associated with bolus injections, remained elevated during the infusion (2 h), but rapidly decreased after infusion was stopped. Thirty seven horses with 38 episodes of naturally occurring gastrointestinal or septicaemic disease were assayed for LPS. Eight episodes involving gastrointestinal disease and eight involving septicaemic disease were positive for LPS. It is concluded that the LAL assay is sensitive and reliable for detecting LPS in equine plasma and it may have clinical value for establishing the severity of endotoxaemia or for distinguishing between septic and non-septic conditions. Problems of rapid clearance of LPS from plasma, low concentrations, the possibility of sample contamination, and the time and method of sample procurement remain to be addressed." @default.
- W2169235461 created "2016-06-24" @default.
- W2169235461 creator A5002339791 @default.
- W2169235461 creator A5041044241 @default.
- W2169235461 creator A5044497219 @default.
- W2169235461 creator A5078778751 @default.
- W2169235461 creator A5086495394 @default.
- W2169235461 creator A5091492798 @default.
- W2169235461 date "1989-06-01" @default.
- W2169235461 modified "2023-09-27" @default.
- W2169235461 title "Plasma endotoxin concentrations in experimental and clinical equine subjects" @default.
- W2169235461 cites W1726769027 @default.
- W2169235461 cites W1979510787 @default.
- W2169235461 cites W1995626394 @default.
- W2169235461 cites W2005797047 @default.
- W2169235461 cites W2055922349 @default.
- W2169235461 cites W2075794306 @default.
- W2169235461 cites W2140944316 @default.
- W2169235461 cites W2164099992 @default.
- W2169235461 cites W2297540397 @default.
- W2169235461 cites W2502670554 @default.
- W2169235461 doi "https://doi.org/10.1111/j.2042-3306.1989.tb05650.x" @default.
- W2169235461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9118101" @default.
- W2169235461 hasPublicationYear "1989" @default.
- W2169235461 type Work @default.
- W2169235461 sameAs 2169235461 @default.
- W2169235461 citedByCount "73" @default.
- W2169235461 countsByYear W21692354612012 @default.
- W2169235461 countsByYear W21692354612013 @default.
- W2169235461 countsByYear W21692354612014 @default.
- W2169235461 countsByYear W21692354612015 @default.
- W2169235461 countsByYear W21692354612016 @default.
- W2169235461 countsByYear W21692354612017 @default.
- W2169235461 countsByYear W21692354612019 @default.
- W2169235461 countsByYear W21692354612020 @default.
- W2169235461 countsByYear W21692354612021 @default.
- W2169235461 countsByYear W21692354612023 @default.
- W2169235461 crossrefType "journal-article" @default.
- W2169235461 hasAuthorship W2169235461A5002339791 @default.
- W2169235461 hasAuthorship W2169235461A5041044241 @default.
- W2169235461 hasAuthorship W2169235461A5044497219 @default.
- W2169235461 hasAuthorship W2169235461A5078778751 @default.
- W2169235461 hasAuthorship W2169235461A5086495394 @default.
- W2169235461 hasAuthorship W2169235461A5091492798 @default.
- W2169235461 hasConcept C126322002 @default.
- W2169235461 hasConcept C151730666 @default.
- W2169235461 hasConcept C2776040547 @default.
- W2169235461 hasConcept C2776487282 @default.
- W2169235461 hasConcept C2777956836 @default.
- W2169235461 hasConcept C2778754761 @default.
- W2169235461 hasConcept C2780762169 @default.
- W2169235461 hasConcept C43376680 @default.
- W2169235461 hasConcept C71924100 @default.
- W2169235461 hasConcept C86803240 @default.
- W2169235461 hasConcept C90924648 @default.
- W2169235461 hasConceptScore W2169235461C126322002 @default.
- W2169235461 hasConceptScore W2169235461C151730666 @default.
- W2169235461 hasConceptScore W2169235461C2776040547 @default.
- W2169235461 hasConceptScore W2169235461C2776487282 @default.
- W2169235461 hasConceptScore W2169235461C2777956836 @default.
- W2169235461 hasConceptScore W2169235461C2778754761 @default.
- W2169235461 hasConceptScore W2169235461C2780762169 @default.
- W2169235461 hasConceptScore W2169235461C43376680 @default.
- W2169235461 hasConceptScore W2169235461C71924100 @default.
- W2169235461 hasConceptScore W2169235461C86803240 @default.
- W2169235461 hasConceptScore W2169235461C90924648 @default.
- W2169235461 hasIssue "S7" @default.
- W2169235461 hasLocation W21692354611 @default.
- W2169235461 hasLocation W21692354612 @default.
- W2169235461 hasOpenAccess W2169235461 @default.
- W2169235461 hasPrimaryLocation W21692354611 @default.
- W2169235461 hasRelatedWork W1964084028 @default.
- W2169235461 hasRelatedWork W1964505323 @default.
- W2169235461 hasRelatedWork W2079323523 @default.
- W2169235461 hasRelatedWork W2117661560 @default.
- W2169235461 hasRelatedWork W2164099992 @default.
- W2169235461 hasRelatedWork W2169235461 @default.
- W2169235461 hasRelatedWork W2375010924 @default.
- W2169235461 hasRelatedWork W29408108 @default.
- W2169235461 hasRelatedWork W3010174998 @default.
- W2169235461 hasRelatedWork W2414549945 @default.
- W2169235461 hasVolume "21" @default.
- W2169235461 isParatext "false" @default.
- W2169235461 isRetracted "false" @default.
- W2169235461 magId "2169235461" @default.
- W2169235461 workType "article" @default.