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• W2169245611 abstract "The advent of combinatorial chemistry was one of the most important developments, that has significantly contributed to the drug discovery process. Within just a few years, its initial concept aimed at production of libraries containing huge number of compounds (thousands to millions), so called screening libraries, has shifted towards preparation of small and medium-sized rationally designed libraries. When applicable, the use of solid supports for the generation of libraries has been a real breakthrough in enhancing productivity. With a limited amount of resin and simple manual workups, the split/mix procedure may generate thousands of bead-tethered compounds. Beads can be chemically or physically encoded to facilitate the identification of a hit after the biological assay. Compartmentalization of solid supports using small reactors like teabags, kans or pellicular discrete supports like Lanterns resulted in powerful sort and combine technologies, relying on codes ‘written’ on the reactor, and thus reducing the need for automation and improving the number of compounds synthesized. These methods of solid-phase combinatorial chemistry have been recently supported by introduction of solid-supported reagents and scavenger resins. The first part of this review discusses the general premises of combinatorial chemistry and some methods used in the design of primary and focused combinatorial libraries. The aim of the second part is to present combinatorial chemistry methodologies aimed at discovering bioactive compounds acting on diverse GPCR involved in central nervous system disorders." @default.
• W2169245611 created "2016-06-24" @default.
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• W2169245611 date "2009-08-01" @default.
• W2169245611 modified "2023-10-11" @default.
• W2169245611 title "Combinatorial Chemistry on Solid Support in the Search for Central Nervous System Agents" @default.
• W2169245611 cites W1967369314 @default.
• W2169245611 cites W1970283323 @default.
• W2169245611 cites W1970944828 @default.
• W2169245611 cites W1973507613 @default.
• W2169245611 cites W1977052508 @default.
• W2169245611 cites W1978522979 @default.
• W2169245611 cites W1981269287 @default.
• W2169245611 cites W1981848002 @default.
• W2169245611 cites W1982408943 @default.
• W2169245611 cites W1983346025 @default.
• W2169245611 cites W1984782504 @default.
• W2169245611 cites W1985267805 @default.
• W2169245611 cites W1986170186 @default.
• W2169245611 cites W1990125211 @default.
• W2169245611 cites W1991756526 @default.
• W2169245611 cites W1995998154 @default.
• W2169245611 cites W1996978701 @default.
• W2169245611 cites W1997853284 @default.
• W2169245611 cites W1998130076 @default.
• W2169245611 cites W2001530591 @default.
• W2169245611 cites W2002969589 @default.
• W2169245611 cites W2008000169 @default.
• W2169245611 cites W2008227190 @default.
• W2169245611 cites W2021663918 @default.
• W2169245611 cites W2022512263 @default.
• W2169245611 cites W2028983179 @default.
• W2169245611 cites W2029972763 @default.
• W2169245611 cites W2031415145 @default.
• W2169245611 cites W2034115932 @default.
• W2169245611 cites W2034927957 @default.
• W2169245611 cites W2040602303 @default.
• W2169245611 cites W2040796364 @default.
• W2169245611 cites W2041464056 @default.
• W2169245611 cites W2048939005 @default.
• W2169245611 cites W2053626694 @default.
• W2169245611 cites W2054393089 @default.
• W2169245611 cites W2055812257 @default.
• W2169245611 cites W2060307846 @default.
• W2169245611 cites W2061765994 @default.
• W2169245611 cites W2064313962 @default.
• W2169245611 cites W2065534030 @default.
• W2169245611 cites W2066520242 @default.
• W2169245611 cites W2067364618 @default.
• W2169245611 cites W2069604273 @default.
• W2169245611 cites W2072991635 @default.
• W2169245611 cites W2074197144 @default.
• W2169245611 cites W2074714235 @default.
• W2169245611 cites W2077291226 @default.
• W2169245611 cites W2078689303 @default.
• W2169245611 cites W2081016293 @default.
• W2169245611 cites W2082377197 @default.
• W2169245611 cites W2082491230 @default.
• W2169245611 cites W2085811828 @default.
• W2169245611 cites W2093175395 @default.
• W2169245611 cites W2094954825 @default.
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• W2169245611 cites W2113672336 @default.
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• W2169245611 cites W2125893327 @default.
• W2169245611 cites W2135732933 @default.
• W2169245611 cites W2161723120 @default.
• W2169245611 cites W2172974116 @default.
• W2169245611 cites W2174731743 @default.
• W2169245611 cites W2320556745 @default.
• W2169245611 cites W2792455800 @default.
• W2169245611 cites W2915587780 @default.
• W2169245611 cites W2918128199 @default.
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• W2169245611 doi "https://doi.org/10.2174/138620709788923719" @default.
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