Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169260018> ?p ?o ?g. }
- W2169260018 endingPage "430" @default.
- W2169260018 startingPage "419" @default.
- W2169260018 abstract "Proliferation and differentiation of mammalian central nervous system progenitor cells involve concertedly controlled transcriptional and alternative splicing modulations. Searching for the developmental implications of this programming, we manipulated specific acetylcholinesterase (AChE) splice variants in the embryonic mouse brain. In wild type mice, ‘synaptic’ AChE-S appeared in migrating neurons, whereas the C-terminus cleaved off the stress-induced AChE-R variant associated with migratory radial glial fibers. Antisense suppression of AChE-R reduced neuronal migration, allowing increased proliferation of progenitor cells. In contrast, transgenic overexpression of AChE-R was ineffective, whereas transgenic excess of enzymatically active AChE-S or inactive AChE-Sin suppressed progenitors proliferation alone or both proliferation and neuronal migration, respectively. Our findings attribute to alternative splicing events an interactive major role in neocortical development." @default.
- W2169260018 created "2016-06-24" @default.
- W2169260018 creator A5003680413 @default.
- W2169260018 creator A5066156147 @default.
- W2169260018 creator A5068985314 @default.
- W2169260018 creator A5071487524 @default.
- W2169260018 creator A5076295709 @default.
- W2169260018 date "2005-04-01" @default.
- W2169260018 modified "2023-10-16" @default.
- W2169260018 title "Functional Manipulations of Acetylcholinesterase Splice Variants Highlight Alternative Splicing Contributions to Murine Neocortical Development" @default.
- W2169260018 cites W13712814 @default.
- W2169260018 cites W1487547430 @default.
- W2169260018 cites W1503727145 @default.
- W2169260018 cites W1504484521 @default.
- W2169260018 cites W1508623490 @default.
- W2169260018 cites W1539488577 @default.
- W2169260018 cites W1543151032 @default.
- W2169260018 cites W1559406855 @default.
- W2169260018 cites W1562398969 @default.
- W2169260018 cites W1582081614 @default.
- W2169260018 cites W1660120640 @default.
- W2169260018 cites W1954300187 @default.
- W2169260018 cites W1967677513 @default.
- W2169260018 cites W1972022525 @default.
- W2169260018 cites W1974208182 @default.
- W2169260018 cites W1977592017 @default.
- W2169260018 cites W1979952856 @default.
- W2169260018 cites W1981321743 @default.
- W2169260018 cites W1984447821 @default.
- W2169260018 cites W1986926812 @default.
- W2169260018 cites W1987145582 @default.
- W2169260018 cites W1989915081 @default.
- W2169260018 cites W1993415479 @default.
- W2169260018 cites W1996985790 @default.
- W2169260018 cites W1997878007 @default.
- W2169260018 cites W1999831963 @default.
- W2169260018 cites W2007141302 @default.
- W2169260018 cites W2015262258 @default.
- W2169260018 cites W2016997675 @default.
- W2169260018 cites W2021515035 @default.
- W2169260018 cites W2022274052 @default.
- W2169260018 cites W2023246580 @default.
- W2169260018 cites W2031365941 @default.
- W2169260018 cites W2038401859 @default.
- W2169260018 cites W2040078621 @default.
- W2169260018 cites W2041279982 @default.
- W2169260018 cites W2045507768 @default.
- W2169260018 cites W2047175022 @default.
- W2169260018 cites W2048850968 @default.
- W2169260018 cites W2048975846 @default.
- W2169260018 cites W2062630155 @default.
- W2169260018 cites W2064994363 @default.
- W2169260018 cites W2068921529 @default.
- W2169260018 cites W2072022771 @default.
- W2169260018 cites W2074576411 @default.
- W2169260018 cites W2077630079 @default.
- W2169260018 cites W2081344779 @default.
- W2169260018 cites W2087986428 @default.
- W2169260018 cites W2088256010 @default.
- W2169260018 cites W2091630929 @default.
- W2169260018 cites W2100414555 @default.
- W2169260018 cites W2102505844 @default.
- W2169260018 cites W2103550033 @default.
- W2169260018 cites W2106213543 @default.
- W2169260018 cites W2107014487 @default.
- W2169260018 cites W2118263629 @default.
- W2169260018 cites W2119305109 @default.
- W2169260018 cites W2119624274 @default.
- W2169260018 cites W2125147395 @default.
- W2169260018 cites W2125525665 @default.
- W2169260018 cites W2126486896 @default.
- W2169260018 cites W2130421403 @default.
- W2169260018 cites W2132091762 @default.
- W2169260018 cites W2132691381 @default.
- W2169260018 cites W2137824309 @default.
- W2169260018 cites W2139402373 @default.
- W2169260018 cites W2150848107 @default.
- W2169260018 cites W2151150230 @default.
- W2169260018 cites W2156511976 @default.
- W2169260018 cites W2158386063 @default.
- W2169260018 cites W2159005901 @default.
- W2169260018 cites W2163590573 @default.
- W2169260018 cites W2171150152 @default.
- W2169260018 cites W2171641108 @default.
- W2169260018 cites W2414214178 @default.
- W2169260018 doi "https://doi.org/10.1093/cercor/bhh145" @default.
- W2169260018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15749986" @default.
- W2169260018 hasPublicationYear "2005" @default.
- W2169260018 type Work @default.
- W2169260018 sameAs 2169260018 @default.
- W2169260018 citedByCount "72" @default.
- W2169260018 countsByYear W21692600182012 @default.
- W2169260018 countsByYear W21692600182013 @default.
- W2169260018 countsByYear W21692600182014 @default.
- W2169260018 countsByYear W21692600182015 @default.
- W2169260018 countsByYear W21692600182016 @default.
- W2169260018 countsByYear W21692600182017 @default.
- W2169260018 countsByYear W21692600182019 @default.