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• W2169264462 abstract "Increased physical activity is associated with decreased risk of several types of cancer, but underlying mechanisms are poorly understood. Angiogenesis, in which new blood vessels are formed, is common to adipose tissue formation/remodeling and tumor vascularization.We examined effects of a 12-month 45 minutes/day, 5 days/week moderate-intensity aerobic exercise intervention on four serum markers of angiogenesis in 173 sedentary, overweight, postmenopausal women, 50 to 75 years, randomized to intervention versus stretching control. Circulating levels of positive regulators of angiogenesis [VEGF, osteopontin (OPN), plasminogen activator inhibitor-1 (PAI-1)], and the negative regulator pigment epithelium-derived factor (PEDF), were measured by immunoassay at baseline and 12 months. Changes were compared using generalized estimating equations, adjusting for baseline levels of analytes and body mass index (BMI).VEGF, OPN, or PAI-1 levels did not differ by intervention arm. Participants randomized to exercise significantly reduced PEDF (-3.7%) versus controls (+3.0%; P = 0.009). Reductions in fat mass were significantly associated with reductions in PAI-1 (Ptrend = 0.03; Ptrend = 0.02) and PEDF (Ptrend = 0.002; Ptrend = 0.01) compared with controls, or to those who gained any fat mass respectively. There was a significant association between decreases in VO2max, and increased reductions in PEDF (Ptrend = 0.03), compared with participants who increased their level of fitness.Fat loss reduces circulating PAI-1 and PEDF. Changes in VO2max are associated with alterations in PEDF, but these associations are complex.Unexpected reductions in PEDF with decreasing fat mass, and with decreasing VO2max, warrant further study, including examining the effects of different types and intensities of exercise; and role of dietary weight-loss with and without exercise." @default.
• W2169264462 created "2016-06-24" @default.
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• W2169264462 date "2014-04-01" @default.
• W2169264462 modified "2023-10-13" @default.
• W2169264462 title "Effect of a 12-Month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: A Randomized Controlled Trial" @default.
• W2169264462 cites W1490422996 @default.
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• W2169264462 cites W1589339270 @default.
• W2169264462 cites W178954517 @default.
• W2169264462 cites W1864871585 @default.
• W2169264462 cites W1964036966 @default.
• W2169264462 cites W1966706607 @default.
• W2169264462 cites W1971992633 @default.
• W2169264462 cites W1976221474 @default.
• W2169264462 cites W1979402100 @default.
• W2169264462 cites W1979999673 @default.
• W2169264462 cites W1980909734 @default.
• W2169264462 cites W1982967084 @default.
• W2169264462 cites W1984031268 @default.
• W2169264462 cites W1985804036 @default.
• W2169264462 cites W1986878490 @default.
• W2169264462 cites W1987784351 @default.
• W2169264462 cites W1990646545 @default.
• W2169264462 cites W1999239339 @default.
• W2169264462 cites W2003801671 @default.
• W2169264462 cites W2005941387 @default.
• W2169264462 cites W2008860066 @default.
• W2169264462 cites W2012273417 @default.
• W2169264462 cites W2015508837 @default.
• W2169264462 cites W2019336811 @default.
• W2169264462 cites W2020671507 @default.
• W2169264462 cites W2022084143 @default.
• W2169264462 cites W2024008844 @default.
• W2169264462 cites W2027442301 @default.
• W2169264462 cites W2037082427 @default.
• W2169264462 cites W2046984560 @default.
• W2169264462 cites W2047578674 @default.
• W2169264462 cites W2048434204 @default.
• W2169264462 cites W2048767933 @default.
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• W2169264462 cites W2053249023 @default.
• W2169264462 cites W2060730575 @default.
• W2169264462 cites W2060899732 @default.
• W2169264462 cites W2066968550 @default.
• W2169264462 cites W2068472192 @default.
• W2169264462 cites W2071342389 @default.
• W2169264462 cites W2072454574 @default.
• W2169264462 cites W2075035517 @default.
• W2169264462 cites W2078921740 @default.
• W2169264462 cites W2085351616 @default.
• W2169264462 cites W2086690729 @default.
• W2169264462 cites W2087460127 @default.
• W2169264462 cites W2093969963 @default.
• W2169264462 cites W2095598121 @default.
• W2169264462 cites W2095847870 @default.
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• W2169264462 cites W2099727391 @default.
• W2169264462 cites W2100390707 @default.
• W2169264462 cites W2100962095 @default.
• W2169264462 cites W2103878518 @default.
• W2169264462 cites W2110141259 @default.
• W2169264462 cites W2111796479 @default.
• W2169264462 cites W2112150914 @default.
• W2169264462 cites W2119173161 @default.
• W2169264462 cites W2124466296 @default.
• W2169264462 cites W2127187614 @default.
• W2169264462 cites W2130370096 @default.
• W2169264462 cites W2131703274 @default.
• W2169264462 cites W2132890490 @default.
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• W2169264462 cites W2139716106 @default.
• W2169264462 cites W2141550792 @default.
• W2169264462 cites W2146139106 @default.
• W2169264462 cites W2149552945 @default.
• W2169264462 cites W2150776809 @default.
• W2169264462 cites W2152946496 @default.
• W2169264462 cites W2172146832 @default.
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• W2169264462 doi "https://doi.org/10.1158/1055-9965.epi-13-1155" @default.
• W2169264462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3976800" @default.
• W2169264462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24501378" @default.
• W2169264462 hasPublicationYear "2014" @default.
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