FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169264762> ?p ?o ?g. }

• W2169264762 endingPage "173" @default.
• W2169264762 startingPage "164" @default.
• W2169264762 abstract "Abstract: T cells expressing the appropriate T-cell receptor Vβ chain proliferate in response to Staphylococcus enterotoxin A (SEA) pulsed antigen-presenting cells (APQ, whereas other T cells do not (SEA “non-re-sponders”). Activated human T cells express MHC class II molecules that are high affinity receptors for SEA. Here we show that, in the absence of APC, SEA induces a profound inhibition of IL-15-driven proliferation in MHC class II+, human SEA-“responder” T-cell lines. In contrast, proliferation induced by phorbol esther (PMA) was enhanced by SEA. The inhibitory effect on cytokine-mediated mitogenesis correlates with an inhibition of EL-2Rβ expression and ligand-induced tyrosine phosphorylation of IL.-2R. Cyclo-sporin A (CyA), an inhibitor of the protein phosphatase (PP2B) calcineurin, strongly inhibits the SEA-induced modulations of cytokine receptor expression. Moreover, CyA inhibits both the anti-mitogenic effect of SEA on cyto-kine-induced proliferation and the pro-mitogenic effect of PMA. In contrast, inhibitors of PP1, PP2A, protein kinase C (PKC), phosphatidyl-inositol-3-kinase (PI-3K) and mammalian target of rapamycin (mTOR) are unable to inhibit the effects of SEA. In a SEA “non-responder” T-cell clone obtained from the affected skin of a patient with psoriasis vulgaris, SEA does not inhibit IL-2Rβ expression and IL-15-driven proliferation. On the contrary, SEA enhances IL-15- and IL-2-induced proliferation via a CyA-sensitive pathway in this T-cell clone. In conclusion, the present data show that (i) SEA selectively inhibits IL-15- (but not PMA-) mediated proliferation in SEA “re-sponder” T cells, (ii) SEA enhances cytokine-driven growth in psoriasis T cells with a “non-responder” phenotype, and (iii) crosstalk between SEA receptors and the LL-15R (and IL-2R) pathway is mediated via a PP2B-de-pendent and PP1/PP2A-, PKC-, PI-3 kinase- and mTOR-independent pathway in human T-cell lines." @default.
• W2169264762 created "2016-06-24" @default.
• W2169264762 creator A5003618240 @default.
• W2169264762 creator A5004078001 @default.
• W2169264762 creator A5023889268 @default.
• W2169264762 creator A5053953985 @default.
• W2169264762 creator A5057500836 @default.
• W2169264762 creator A5078834047 @default.
• W2169264762 creator A5082689834 @default.
• W2169264762 date "2008-09-30" @default.
• W2169264762 modified "2023-10-18" @default.
• W2169264762 title "Staphylococcus enterotoxin A modulates interleukin 15-induced signaling and mitogenesis in human T cells" @default.
• W2169264762 cites W1428006903 @default.
• W2169264762 cites W1486672230 @default.
• W2169264762 cites W1496099463 @default.
• W2169264762 cites W1496241759 @default.
• W2169264762 cites W1529396499 @default.
• W2169264762 cites W1549922507 @default.
• W2169264762 cites W1573799042 @default.
• W2169264762 cites W1593636339 @default.
• W2169264762 cites W1794445781 @default.
• W2169264762 cites W1797700808 @default.
• W2169264762 cites W1895889010 @default.
• W2169264762 cites W1922668115 @default.
• W2169264762 cites W1976262436 @default.
• W2169264762 cites W1977464777 @default.
• W2169264762 cites W1986136585 @default.
• W2169264762 cites W1989233089 @default.
• W2169264762 cites W2002575313 @default.
• W2169264762 cites W2002903751 @default.
• W2169264762 cites W2017072222 @default.
• W2169264762 cites W2027306447 @default.
• W2169264762 cites W2039231373 @default.
• W2169264762 cites W2039628828 @default.
• W2169264762 cites W2049478058 @default.
• W2169264762 cites W2068767330 @default.
• W2169264762 cites W2070335194 @default.
• W2169264762 cites W2072857434 @default.
• W2169264762 cites W2073117081 @default.
• W2169264762 cites W2076706420 @default.
• W2169264762 cites W2077992059 @default.
• W2169264762 cites W2080470303 @default.
• W2169264762 cites W2091217693 @default.
• W2169264762 cites W2101276248 @default.
• W2169264762 cites W2130205927 @default.
• W2169264762 cites W2160659449 @default.
• W2169264762 cites W2186507474 @default.
• W2169264762 cites W75858226 @default.
• W2169264762 doi "https://doi.org/10.1111/j.1399-0039.1998.tb02961.x" @default.
• W2169264762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9510372" @default.
• W2169264762 hasPublicationYear "2008" @default.
• W2169264762 type Work @default.
• W2169264762 sameAs 2169264762 @default.
• W2169264762 citedByCount "3" @default.
• W2169264762 crossrefType "journal-article" @default.
• W2169264762 hasAuthorship W2169264762A5003618240 @default.
• W2169264762 hasAuthorship W2169264762A5004078001 @default.
• W2169264762 hasAuthorship W2169264762A5023889268 @default.
• W2169264762 hasAuthorship W2169264762A5053953985 @default.
• W2169264762 hasAuthorship W2169264762A5057500836 @default.
• W2169264762 hasAuthorship W2169264762A5078834047 @default.
• W2169264762 hasAuthorship W2169264762A5082689834 @default.
• W2169264762 hasConcept C153911025 @default.
• W2169264762 hasConcept C195794163 @default.
• W2169264762 hasConcept C203014093 @default.
• W2169264762 hasConcept C2776090121 @default.
• W2169264762 hasConcept C2778690821 @default.
• W2169264762 hasConcept C36333154 @default.
• W2169264762 hasConcept C62478195 @default.
• W2169264762 hasConcept C86803240 @default.
• W2169264762 hasConcept C8891405 @default.
• W2169264762 hasConcept C95444343 @default.
• W2169264762 hasConceptScore W2169264762C153911025 @default.
• W2169264762 hasConceptScore W2169264762C195794163 @default.
• W2169264762 hasConceptScore W2169264762C203014093 @default.
• W2169264762 hasConceptScore W2169264762C2776090121 @default.
• W2169264762 hasConceptScore W2169264762C2778690821 @default.
• W2169264762 hasConceptScore W2169264762C36333154 @default.
• W2169264762 hasConceptScore W2169264762C62478195 @default.
• W2169264762 hasConceptScore W2169264762C86803240 @default.
• W2169264762 hasConceptScore W2169264762C8891405 @default.
• W2169264762 hasConceptScore W2169264762C95444343 @default.
• W2169264762 hasIssue "2" @default.
• W2169264762 hasLocation W21692647621 @default.
• W2169264762 hasLocation W21692647622 @default.
• W2169264762 hasOpenAccess W2169264762 @default.
• W2169264762 hasPrimaryLocation W21692647621 @default.
• W2169264762 hasRelatedWork W1574668619 @default.
• W2169264762 hasRelatedWork W1884572537 @default.
• W2169264762 hasRelatedWork W1989096174 @default.
• W2169264762 hasRelatedWork W2001222251 @default.
• W2169264762 hasRelatedWork W2030349478 @default.
• W2169264762 hasRelatedWork W2037527030 @default.
• W2169264762 hasRelatedWork W2111438490 @default.
• W2169264762 hasRelatedWork W2133381038 @default.
• W2169264762 hasRelatedWork W2158755602 @default.
• W2169264762 hasRelatedWork W2784282460 @default.
• W2169264762 hasVolume "51" @default.

• next