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- W2169271495 abstract "Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems.This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in an independent GWAS data including 1802 SZ cases and 1447 controls; (2) profile genome-wide miRNA expression in blood collected from 15 early-onset SZ (EOS) cases and 15 healthy controls; and (3) construct a miRNA-messenger RNA (mRNA) regulatory network using our previous genome-wide mRNA expression data generated from a separate sample of 18 EOS cases and 12 healthy controls.Our findings indicate that: (1) In genes associated with the control of miRNAs, there are approximately 50% more RVs in SZ cases than in controls (P ≤ 2.62E-10); (2) The observed lower miRNA activity in EOS patients compared with the healthy controls suggests that miRNAs are abnormally downregulated; (3) There exists a predicted regulatory network among some downregulated miRNAs and some upregulated mRNAs.Collectively, results from all 3 lines of evidence, suggest that the genetically based dysregulation of miRNA systems undermines miRNAs' inhibitory effects, resulting in the abnormal upregulation of genome transcription in the development of SZ." @default.
- W2169271495 created "2016-06-24" @default.
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- W2169271495 date "2014-11-26" @default.
- W2169271495 modified "2023-10-12" @default.
- W2169271495 title "Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia" @default.
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- W2169271495 cites W2045761141 @default.
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- W2169271495 cites W2054585593 @default.
- W2169271495 cites W2057460717 @default.
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- W2169271495 cites W2088390270 @default.
- W2169271495 cites W2093150481 @default.
- W2169271495 cites W2096301549 @default.
- W2169271495 cites W2097349182 @default.
- W2169271495 cites W2097804771 @default.
- W2169271495 cites W2103164878 @default.
- W2169271495 cites W2116795476 @default.
- W2169271495 cites W2121247237 @default.
- W2169271495 cites W2124499207 @default.
- W2169271495 cites W2132123917 @default.
- W2169271495 cites W2132554694 @default.
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- W2169271495 cites W2150056340 @default.
- W2169271495 cites W2151359426 @default.
- W2169271495 cites W2151578735 @default.
- W2169271495 cites W2157150947 @default.
- W2169271495 cites W2158246535 @default.
- W2169271495 cites W2159675211 @default.
- W2169271495 cites W2160410603 @default.
- W2169271495 cites W2161527093 @default.
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- W2169271495 doi "https://doi.org/10.1093/schbul/sbu148" @default.
- W2169271495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393688" @default.
- W2169271495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25429046" @default.
- W2169271495 hasPublicationYear "2014" @default.
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