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• W2169277660 endingPage "390" @default.
• W2169277660 startingPage "378" @default.
• W2169277660 abstract "ABSTRACT Type IV pili (T4P) are ubiquitous bacterial cell surface structures that undergo cycles of extension, adhesion, and retraction. T4P function depends on a highly conserved envelope-spanning macromolecular machinery consisting of 10 proteins that localizes polarly in Myxococcus xanthus . Using this localization, we investigated the entire T4P machinery assembly pathway by systematically profiling the stability of all and the localization of eight of these proteins in the absence of other T4P machinery proteins as well as by mapping direct protein-protein interactions. Our experiments uncovered a sequential, outside-in pathway starting with the outer membrane (OM) PilQ secretin ring. PilQ recruits a subcomplex consisting of the inner membrane (IM) lipoprotein PilP and the integral IM proteins PilN and PilO by direct interaction with the periplasmic domain of PilP. The PilP/PilN/PilO subcomplex recruits the cytoplasmic PilM protein, by direct interaction between PilN and PilM, and the integral IM protein PilC. The PilB/PilT ATPases that power extension/retraction localize independently of other T4P machinery proteins. Thus, assembly of the T4P machinery initiates with formation of the OM secretin ring and continues inwards over the periplasm and IM to the cytoplasm." @default.
• W2169277660 created "2016-06-24" @default.
• W2169277660 creator A5036670527 @default.
• W2169277660 creator A5074705819 @default.
• W2169277660 creator A5090108171 @default.
• W2169277660 date "2014-01-15" @default.
• W2169277660 modified "2023-10-05" @default.
• W2169277660 title "Outside-In Assembly Pathway of the Type IV Pilus System in Myxococcus xanthus" @default.
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• W2169277660 doi "https://doi.org/10.1128/jb.01094-13" @default.
• W2169277660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3911261" @default.
• W2169277660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24187092" @default.
• W2169277660 hasPublicationYear "2014" @default.
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