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- W2169294211 abstract "Radioimmunoassays have been developed using monoclonal antibodies from hybridomas raised against bovine serum albumin conjugates of O 6 -n-butylguanosine, O 2 -n-butylthymidine riboside and O 4 -n-butylthymidine riboside. The assays showed 50% inhibition of binding of specific [ 3 H]butyl-deoxynucleosides by 0.044, 0.069 and 0.45 pmole of cold O 6 -n-butyldeoxyguanosine, O 2 -n-butylthymidine and O 4 -n-butylthymidine respectively, corresponding to affinity constants of 2.7 × 10 10 , 1.1 × 10 10 and 8.8 × 10 8 respectively. In competitive radioimmunoassays a similar degree of inhibition required ∼10 7 -fold higher concentrations of normal deoxy-nucleotides. From the relative inhibitions produced by a wide range of alkylated and normal nucleosides and bases we conclude that each antibody primarily recognises butylation, as compared to other alkylations, at the sites specified by the immunogen. The radioimmunoassays should be suitable for the detection of these potentially promutagenic lesions in digests of DNA exposed to low (biological) levels of butylation." @default.
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- W2169294211 date "1982-01-01" @default.
- W2169294211 modified "2023-09-26" @default.
- W2169294211 title "Sensitive radioimmunoassays for O6-n-butyldeoxyguanosine, O2-n-butylthymidine and O4-n-butylthymidine" @default.
- W2169294211 doi "https://doi.org/10.1093/carcin/3.5.547" @default.
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