FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169304194> ?p ?o ?g. }

• W2169304194 endingPage "10475" @default.
• W2169304194 startingPage "10470" @default.
• W2169304194 abstract "Neuropilin-1 (NRP1) is a cell-surface receptor for both vascular endothelial growth factor(165) (VEGF(165)) and class 3 semaphorins that is expressed by neurons and endothelial cells. NRP1 is required for normal developmental angiogenesis in mice. The zebrafish is an excellent system for analyzing vascular development. Zebrafish intersegmental vessels correspond to mammalian capillary sprouts, whereas the axial vessels correspond to larger blood vessels, such as arteries. The zebrafish NRP1 gene (znrp1) was isolated and when overexpressed in cells, zNRP1 protein was a functional receptor for human VEGF(165). Whole-mount in situ hybridization showed that transcripts for znrp1 during embryonic and early larval development were detected mainly in neuronal and vascular tissues. Morpholino-mediated knockdown of zNRP1 in embryos resulted in vascular defects, most notably impaired circulation in the intersegmental vessels. Circulation via trunk axial vessels was not affected. Embryos treated with VEGF receptor-2 kinase inhibitor had a similar intersegmental vessel defect suggesting that knockdown of zNRP1 reduces VEGF activity. To determine whether NRP1 and VEGF activities were interdependent in vivo, zNRP1 and VEGF morpholinos were coinjected into embryos at concentrations that individually did not significantly inhibit blood vessel development. The result was a potent inhibition of blood cell circulation via both intersegmental and axial vessels demonstrating that VEGF and NRP1 act synergistically to promote a functional circulatory system. These results provide the first physiological demonstration that NRP1 regulates angiogenesis through a VEGF-dependent pathway." @default.
• W2169304194 created "2016-06-24" @default.
• W2169304194 creator A5006176750 @default.
• W2169304194 creator A5006353545 @default.
• W2169304194 creator A5030279380 @default.
• W2169304194 creator A5056525940 @default.
• W2169304194 creator A5070544438 @default.
• W2169304194 creator A5086372369 @default.
• W2169304194 date "2002-07-25" @default.
• W2169304194 modified "2023-10-02" @default.
• W2169304194 title "Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish" @default.
• W2169304194 cites W1562759933 @default.
• W2169304194 cites W1590774636 @default.
• W2169304194 cites W1762724222 @default.
• W2169304194 cites W1875913653 @default.
• W2169304194 cites W1969328947 @default.
• W2169304194 cites W1977059167 @default.
• W2169304194 cites W1987868279 @default.
• W2169304194 cites W1990983421 @default.
• W2169304194 cites W1998756807 @default.
• W2169304194 cites W2001516056 @default.
• W2169304194 cites W2003742281 @default.
• W2169304194 cites W2005494875 @default.
• W2169304194 cites W2010092400 @default.
• W2169304194 cites W2013184812 @default.
• W2169304194 cites W2021087194 @default.
• W2169304194 cites W2022950801 @default.
• W2169304194 cites W2028737492 @default.
• W2169304194 cites W2045247659 @default.
• W2169304194 cites W2060661590 @default.
• W2169304194 cites W2065668335 @default.
• W2169304194 cites W2067817921 @default.
• W2169304194 cites W2084228496 @default.
• W2169304194 cites W2093498435 @default.
• W2169304194 cites W2098732827 @default.
• W2169304194 cites W2101020025 @default.
• W2169304194 cites W2125349610 @default.
• W2169304194 cites W2141046053 @default.
• W2169304194 cites W2344433860 @default.
• W2169304194 doi "https://doi.org/10.1073/pnas.162366299" @default.
• W2169304194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/124944" @default.
• W2169304194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12142468" @default.
• W2169304194 hasPublicationYear "2002" @default.
• W2169304194 type Work @default.
• W2169304194 sameAs 2169304194 @default.
• W2169304194 citedByCount "194" @default.
• W2169304194 countsByYear W21693041942012 @default.
• W2169304194 countsByYear W21693041942013 @default.
• W2169304194 countsByYear W21693041942014 @default.
• W2169304194 countsByYear W21693041942015 @default.
• W2169304194 countsByYear W21693041942016 @default.
• W2169304194 countsByYear W21693041942017 @default.
• W2169304194 countsByYear W21693041942018 @default.
• W2169304194 countsByYear W21693041942019 @default.
• W2169304194 countsByYear W21693041942020 @default.
• W2169304194 countsByYear W21693041942021 @default.
• W2169304194 countsByYear W21693041942022 @default.
• W2169304194 countsByYear W21693041942023 @default.
• W2169304194 crossrefType "journal-article" @default.
• W2169304194 hasAuthorship W2169304194A5006176750 @default.
• W2169304194 hasAuthorship W2169304194A5006353545 @default.
• W2169304194 hasAuthorship W2169304194A5030279380 @default.
• W2169304194 hasAuthorship W2169304194A5056525940 @default.
• W2169304194 hasAuthorship W2169304194A5070544438 @default.
• W2169304194 hasAuthorship W2169304194A5086372369 @default.
• W2169304194 hasBestOaLocation W21693041941 @default.
• W2169304194 hasConcept C104317684 @default.
• W2169304194 hasConcept C106420622 @default.
• W2169304194 hasConcept C132538176 @default.
• W2169304194 hasConcept C136571751 @default.
• W2169304194 hasConcept C146285616 @default.
• W2169304194 hasConcept C14858245 @default.
• W2169304194 hasConcept C167734588 @default.
• W2169304194 hasConcept C170493617 @default.
• W2169304194 hasConcept C173396325 @default.
• W2169304194 hasConcept C201750760 @default.
• W2169304194 hasConcept C2776878037 @default.
• W2169304194 hasConcept C2777025900 @default.
• W2169304194 hasConcept C2780394083 @default.
• W2169304194 hasConcept C28328180 @default.
• W2169304194 hasConcept C34425596 @default.
• W2169304194 hasConcept C502942594 @default.
• W2169304194 hasConcept C54355233 @default.
• W2169304194 hasConcept C55493867 @default.
• W2169304194 hasConcept C60781801 @default.
• W2169304194 hasConcept C81885089 @default.
• W2169304194 hasConcept C86803240 @default.
• W2169304194 hasConcept C95444343 @default.
• W2169304194 hasConceptScore W2169304194C104317684 @default.
• W2169304194 hasConceptScore W2169304194C106420622 @default.
• W2169304194 hasConceptScore W2169304194C132538176 @default.
• W2169304194 hasConceptScore W2169304194C136571751 @default.
• W2169304194 hasConceptScore W2169304194C146285616 @default.
• W2169304194 hasConceptScore W2169304194C14858245 @default.
• W2169304194 hasConceptScore W2169304194C167734588 @default.
• W2169304194 hasConceptScore W2169304194C170493617 @default.
• W2169304194 hasConceptScore W2169304194C173396325 @default.
• W2169304194 hasConceptScore W2169304194C201750760 @default.

• next