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• W2169309331 abstract "ABSTRACT With the emergence of many antibiotic-resistant strains worldwide, antimicrobial peptides (AMPs) are being evaluated as promising alternatives to conventional antibiotics. P3, a novel hemoglobin peptide derived from bovine erythrocytes, exhibited modest antimicrobial activity in vitro . We evaluated the antimicrobial activities of P3 and an analog, JH-3, both in vitro and in vivo . The MICs of P3 and JH-3 ranged from 3.125 μg/ml to 50 μg/ml when a wide spectrum of bacteria was tested, including multidrug-resistant strains. P3 killed bacteria within 30 min by disrupting the bacterial cytoplasmic membrane and disturbing the intracellular calcium balance. Circular dichroism (CD) spectrometry showed that P3 assumed an α-helical conformation in bacterial lipid membranes, which was indispensable for antimicrobial activity. Importantly, the 50% lethal dose (LD 50 ) of JH-3 was 180 mg/kg of mouse body weight after intraperitoneal (i.p.) injection, and no death was observed at any dose up to 240 mg/kg body weight following subcutaneous (s.c.) injection. Furthermore, JH-3 significantly decreased the bacterial count and rescued infected mice in a model of mouse bacteremia. In conclusion, P3 and an analog exhibited potent antimicrobial activities and relatively low toxicities in a mouse model, indicating that they may be useful for treating infections caused by drug-resistant bacteria." @default.
• W2169309331 created "2016-06-24" @default.
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• W2169309331 date "2015-05-01" @default.
• W2169309331 modified "2023-10-14" @default.
• W2169309331 title "Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial Membranes <i>In Vitro</i> and Display Activity against Drug-Resistant Bacteria in a Mouse Model" @default.
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• W2169309331 doi "https://doi.org/10.1128/aac.04932-14" @default.
• W2169309331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4394822" @default.
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