FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169312302> ?p ?o ?g. }

• W2169312302 endingPage "304" @default.
• W2169312302 startingPage "297" @default.
• W2169312302 abstract "The causative agent of ovine footrot, the gram-negative anaerobe Dichelobacter nodosus, produces polar type IV fimbriae, which are the major protective antigens. The D. nodosus genes fimN, fimO, and fimP are homologs of the Pseudomonas aeruginosa fimbrial assembly genes, pilB, pilC, and pilD, respectively. Both the pilD and fimP genes encode prepilin peptidases that are responsible for cleavage of the leader sequence from the immature fimbrial subunit. To investigate the functional similarity of the fimbrial biogenesis systems from these organisms, the D. nodosus genes were introduced into P. aeruginosa strains carrying mutations in the homologous genes. Analysis of the resultant derivatives showed that the fimP gene complemented a pilD mutant of P. aeruginosa for both fimbrial assembly and protein secretion. However, the fimN and fimO genes did not complement pilB or pilC mutants, respectively. These results suggest that although the PilD prepilin peptidase can be functionally replaced by the heterologous FimP protein, the function of the PilB and PilC proteins may require binding or catalytic domains specific for the P. aeruginosa fimbrial assembly system. The transcriptional organization and regulation of the fimNOP gene region were also examined. The results of reverse transcriptase PCR and primer extension analysis suggested that these genes form an operon transcribed from two sigma70-type promoters located upstream of ORFM, an open reading frame proximal to fimN. Transcription of the D. nodosus fimbrial subunit was found to increase in cells grown on solid media, and it was postulated that this regulatory effect may be of significance in the infected footrot lesion." @default.
• W2169312302 created "2016-06-24" @default.
• W2169312302 creator A5053064309 @default.
• W2169312302 creator A5063710240 @default.
• W2169312302 creator A5079931536 @default.
• W2169312302 creator A5088729205 @default.
• W2169312302 date "1998-01-01" @default.
• W2169312302 modified "2023-10-12" @default.
• W2169312302 title "Complementation Analysis of the <i>Dichelobacter nodosus fimN</i> , <i>fimO</i> , and <i>fimP</i> Genes in <i>Pseudomonas aeruginosa</i> and Transcriptional Analysis of the <i>fimNOP</i> Gene Region" @default.
• W2169312302 cites W1480682589 @default.
• W2169312302 cites W1482353703 @default.
• W2169312302 cites W1499492011 @default.
• W2169312302 cites W1542007735 @default.
• W2169312302 cites W1543224733 @default.
• W2169312302 cites W1582323836 @default.
• W2169312302 cites W1608164084 @default.
• W2169312302 cites W1710824983 @default.
• W2169312302 cites W1825107431 @default.
• W2169312302 cites W1845147287 @default.
• W2169312302 cites W1914922901 @default.
• W2169312302 cites W1915683180 @default.
• W2169312302 cites W1919785630 @default.
• W2169312302 cites W1925342666 @default.
• W2169312302 cites W1934623513 @default.
• W2169312302 cites W1974072978 @default.
• W2169312302 cites W1978236844 @default.
• W2169312302 cites W1981777358 @default.
• W2169312302 cites W1998591058 @default.
• W2169312302 cites W2003729219 @default.
• W2169312302 cites W2006240928 @default.
• W2169312302 cites W2009076345 @default.
• W2169312302 cites W2019443000 @default.
• W2169312302 cites W2026174297 @default.
• W2169312302 cites W2034694764 @default.
• W2169312302 cites W2034750431 @default.
• W2169312302 cites W2036219298 @default.
• W2169312302 cites W2040934430 @default.
• W2169312302 cites W2041259453 @default.
• W2169312302 cites W2042705580 @default.
• W2169312302 cites W2054691200 @default.
• W2169312302 cites W2057412116 @default.
• W2169312302 cites W2059261210 @default.
• W2169312302 cites W2061700743 @default.
• W2169312302 cites W2077964932 @default.
• W2169312302 cites W2081990552 @default.
• W2169312302 cites W2085290399 @default.
• W2169312302 cites W2087577530 @default.
• W2169312302 cites W2107890692 @default.
• W2169312302 cites W2110160301 @default.
• W2169312302 cites W2120503951 @default.
• W2169312302 cites W2137046453 @default.
• W2169312302 cites W2138111819 @default.
• W2169312302 cites W2140229549 @default.
• W2169312302 cites W2144113817 @default.
• W2169312302 cites W2148948559 @default.
• W2169312302 cites W2154059829 @default.
• W2169312302 cites W2155050113 @default.
• W2169312302 cites W2155247823 @default.
• W2169312302 cites W2157501876 @default.
• W2169312302 cites W2159799356 @default.
• W2169312302 cites W2160540017 @default.
• W2169312302 cites W2161302487 @default.
• W2169312302 cites W2161524167 @default.
• W2169312302 cites W2279821170 @default.
• W2169312302 cites W2289674231 @default.
• W2169312302 cites W3023505883 @default.
• W2169312302 cites W4253230027 @default.
• W2169312302 doi "https://doi.org/10.1128/iai.66.1.297-304.1998" @default.
• W2169312302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/107890" @default.
• W2169312302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9423871" @default.
• W2169312302 hasPublicationYear "1998" @default.
• W2169312302 type Work @default.
• W2169312302 sameAs 2169312302 @default.
• W2169312302 citedByCount "8" @default.
• W2169312302 countsByYear W21693123022013 @default.
• W2169312302 countsByYear W21693123022014 @default.
• W2169312302 countsByYear W21693123022015 @default.
• W2169312302 crossrefType "journal-article" @default.
• W2169312302 hasAuthorship W2169312302A5053064309 @default.
• W2169312302 hasAuthorship W2169312302A5063710240 @default.
• W2169312302 hasAuthorship W2169312302A5079931536 @default.
• W2169312302 hasAuthorship W2169312302A5088729205 @default.
• W2169312302 hasBestOaLocation W21693123021 @default.
• W2169312302 hasConcept C104317684 @default.
• W2169312302 hasConcept C143065580 @default.
• W2169312302 hasConcept C167625842 @default.
• W2169312302 hasConcept C174832134 @default.
• W2169312302 hasConcept C188082640 @default.
• W2169312302 hasConcept C203075996 @default.
• W2169312302 hasConcept C2777637488 @default.
• W2169312302 hasConcept C47289529 @default.
• W2169312302 hasConcept C523546767 @default.
• W2169312302 hasConcept C54355233 @default.
• W2169312302 hasConcept C60987743 @default.
• W2169312302 hasConcept C86803240 @default.
• W2169312302 hasConcept C89423630 @default.
• W2169312302 hasConceptScore W2169312302C104317684 @default.
• W2169312302 hasConceptScore W2169312302C143065580 @default.

• next