Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169313814> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2169313814 endingPage "535" @default.
- W2169313814 startingPage "520" @default.
- W2169313814 abstract "In the present study, LPDs composing of a series of novel synthetic cholesterylated derivatives bearing a cluster of galactose residues and different spacer lengths were prepared for performing target gene delivery to hepatocytes and their physiochemical properties as well as gene transfer efficiency were investigated. In agreement with the “clustering effect” known to occur with more complex oligomeric structures, the addition of galactose residues under optimized spatial arrangement condition invariably increased the transfect efficiency into hepatoma cells, which can be owed to the sufficient binding of galactose ligands to the ASGPR on hepatocytes. However, the gene transfer ability to hepatocytes was not always improved with extended spacer arms, suggesting a spatial binding sites arrangement of the receptor. Moreover, our research has established galactosylated LPDs, specifically, LPDIIb, LPDIIIc, and LPDIVe as potential vectors to deliver special genes into hepatocytes with low toxicity, combining the condensing effect of protamine and the targeting capability of cholesterylated thiogalactosides." @default.
- W2169313814 created "2016-06-24" @default.
- W2169313814 creator A5001421484 @default.
- W2169313814 creator A5001589128 @default.
- W2169313814 creator A5006896948 @default.
- W2169313814 creator A5063515570 @default.
- W2169313814 creator A5064150611 @default.
- W2169313814 creator A5069190300 @default.
- W2169313814 date "2010-01-13" @default.
- W2169313814 modified "2023-10-18" @default.
- W2169313814 title "Novel synthetic LPDs consisting of different cholesterol derivatives for gene transfer into hepatocytes" @default.
- W2169313814 cites W1533643153 @default.
- W2169313814 cites W1587073416 @default.
- W2169313814 cites W1964741678 @default.
- W2169313814 cites W1976507335 @default.
- W2169313814 cites W1995798120 @default.
- W2169313814 cites W1999521674 @default.
- W2169313814 cites W2002685951 @default.
- W2169313814 cites W2005509413 @default.
- W2169313814 cites W2007833198 @default.
- W2169313814 cites W2008073451 @default.
- W2169313814 cites W2014929596 @default.
- W2169313814 cites W2025663809 @default.
- W2169313814 cites W2029175314 @default.
- W2169313814 cites W2030712950 @default.
- W2169313814 cites W2031181465 @default.
- W2169313814 cites W2034273780 @default.
- W2169313814 cites W2042722540 @default.
- W2169313814 cites W2043559206 @default.
- W2169313814 cites W2060262082 @default.
- W2169313814 cites W2068567567 @default.
- W2169313814 cites W2072756663 @default.
- W2169313814 cites W2078810655 @default.
- W2169313814 cites W2104341089 @default.
- W2169313814 cites W2302264968 @default.
- W2169313814 cites W2314642321 @default.
- W2169313814 doi "https://doi.org/10.3109/10611860903548370" @default.
- W2169313814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20067439" @default.
- W2169313814 hasPublicationYear "2010" @default.
- W2169313814 type Work @default.
- W2169313814 sameAs 2169313814 @default.
- W2169313814 citedByCount "4" @default.
- W2169313814 countsByYear W21693138142013 @default.
- W2169313814 countsByYear W21693138142015 @default.
- W2169313814 crossrefType "journal-article" @default.
- W2169313814 hasAuthorship W2169313814A5001421484 @default.
- W2169313814 hasAuthorship W2169313814A5001589128 @default.
- W2169313814 hasAuthorship W2169313814A5006896948 @default.
- W2169313814 hasAuthorship W2169313814A5063515570 @default.
- W2169313814 hasAuthorship W2169313814A5064150611 @default.
- W2169313814 hasAuthorship W2169313814A5069190300 @default.
- W2169313814 hasConcept C104317684 @default.
- W2169313814 hasConcept C12554922 @default.
- W2169313814 hasConcept C185592680 @default.
- W2169313814 hasConcept C2778173381 @default.
- W2169313814 hasConcept C3018928802 @default.
- W2169313814 hasConcept C36857842 @default.
- W2169313814 hasConcept C54009773 @default.
- W2169313814 hasConcept C55493867 @default.
- W2169313814 hasConcept C70721500 @default.
- W2169313814 hasConcept C86803240 @default.
- W2169313814 hasConceptScore W2169313814C104317684 @default.
- W2169313814 hasConceptScore W2169313814C12554922 @default.
- W2169313814 hasConceptScore W2169313814C185592680 @default.
- W2169313814 hasConceptScore W2169313814C2778173381 @default.
- W2169313814 hasConceptScore W2169313814C3018928802 @default.
- W2169313814 hasConceptScore W2169313814C36857842 @default.
- W2169313814 hasConceptScore W2169313814C54009773 @default.
- W2169313814 hasConceptScore W2169313814C55493867 @default.
- W2169313814 hasConceptScore W2169313814C70721500 @default.
- W2169313814 hasConceptScore W2169313814C86803240 @default.
- W2169313814 hasIssue "7" @default.
- W2169313814 hasLocation W21693138141 @default.
- W2169313814 hasLocation W21693138142 @default.
- W2169313814 hasOpenAccess W2169313814 @default.
- W2169313814 hasPrimaryLocation W21693138141 @default.
- W2169313814 hasRelatedWork W1698181273 @default.
- W2169313814 hasRelatedWork W2008069672 @default.
- W2169313814 hasRelatedWork W2008263498 @default.
- W2169313814 hasRelatedWork W2046161792 @default.
- W2169313814 hasRelatedWork W2083520108 @default.
- W2169313814 hasRelatedWork W2105305395 @default.
- W2169313814 hasRelatedWork W2137197106 @default.
- W2169313814 hasRelatedWork W2142560033 @default.
- W2169313814 hasRelatedWork W4251981790 @default.
- W2169313814 hasRelatedWork W4380874015 @default.
- W2169313814 hasVolume "18" @default.
- W2169313814 isParatext "false" @default.
- W2169313814 isRetracted "false" @default.
- W2169313814 magId "2169313814" @default.
- W2169313814 workType "article" @default.