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- W2169314089 endingPage "13" @default.
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- W2169314089 abstract "In pancreatic B- and A-cells, metabolic stimuli regulate biochemical and electrical processes that culminate in Ca2+-influx and release of insulin or glucagon, respectively. Like in other (neuro)endocrine cells, Ca2+-influx triggers the rapid exocytosis of hormone-containing secretory granules. Only a small fraction of granules (<1% in insulin-secreting B-cells) can be released immediately, while the remainder requires translocation to the plasma membrane and further priming for release by several ATP- and Ca2+-dependent reactions. Such functional organization may account for systemic features such as the biphasic time course of glucose-stimulated insulin secretion. Since this release pattern is altered in type-2 diabetes mellitus, it is conceivable that disturbances in the exocytotic machinery underlie the disease. Here I will review recent data from our laboratory relevant for the understanding of these processes in insulin-secreting B-cells and glucagon-secreting A-cells and for the identification of novel targets for antidiabetic drug action. Two aspects are discussed in detail: 1) The importance of a tight interaction between L-type Ca2+-channels and the exocytotic machinery for efficient secretion; and 2) the role of intragranular acidification for the priming of secretory granules and its regulation by a granular 65-kDa sulfonylurea-binding protein." @default.
- W2169314089 created "2016-06-24" @default.
- W2169314089 creator A5001448846 @default.
- W2169314089 date "2003-01-01" @default.
- W2169314089 modified "2023-10-14" @default.
- W2169314089 title "Mechanisms of Exocytosis in Insulin-Secreting B-Cells and Glucagon-Secreting A-Cells" @default.
- W2169314089 cites W1504011172 @default.
- W2169314089 cites W1513511290 @default.
- W2169314089 cites W1561714804 @default.
- W2169314089 cites W1571457734 @default.
- W2169314089 cites W1578136772 @default.
- W2169314089 cites W1581436439 @default.
- W2169314089 cites W1592962814 @default.
- W2169314089 cites W1779889804 @default.
- W2169314089 cites W1807494075 @default.
- W2169314089 cites W1822252127 @default.
- W2169314089 cites W1866455211 @default.
- W2169314089 cites W1954895018 @default.
- W2169314089 cites W1966753445 @default.
- W2169314089 cites W1967281678 @default.
- W2169314089 cites W1967514128 @default.
- W2169314089 cites W1968720990 @default.
- W2169314089 cites W1972322271 @default.
- W2169314089 cites W1974623748 @default.
- W2169314089 cites W1977582731 @default.
- W2169314089 cites W1980852615 @default.
- W2169314089 cites W1982601009 @default.
- W2169314089 cites W1983078818 @default.
- W2169314089 cites W1987946916 @default.
- W2169314089 cites W1988602766 @default.
- W2169314089 cites W1988801692 @default.
- W2169314089 cites W1990220309 @default.
- W2169314089 cites W1992045485 @default.
- W2169314089 cites W2004564781 @default.
- W2169314089 cites W2010986301 @default.
- W2169314089 cites W2013739856 @default.
- W2169314089 cites W2015651475 @default.
- W2169314089 cites W2016242736 @default.
- W2169314089 cites W2017509811 @default.
- W2169314089 cites W2021429888 @default.
- W2169314089 cites W2024710493 @default.
- W2169314089 cites W2026290001 @default.
- W2169314089 cites W2038583764 @default.
- W2169314089 cites W2042559950 @default.
- W2169314089 cites W2044612428 @default.
- W2169314089 cites W2045464110 @default.
- W2169314089 cites W2046901610 @default.
- W2169314089 cites W2047377966 @default.
- W2169314089 cites W2048580360 @default.
- W2169314089 cites W2049043048 @default.
- W2169314089 cites W2050076638 @default.
- W2169314089 cites W2053191479 @default.
- W2169314089 cites W2053559739 @default.
- W2169314089 cites W2054181228 @default.
- W2169314089 cites W2055454610 @default.
- W2169314089 cites W2058595266 @default.
- W2169314089 cites W2060910300 @default.
- W2169314089 cites W2061613461 @default.
- W2169314089 cites W2061936950 @default.
- W2169314089 cites W2062699559 @default.
- W2169314089 cites W2065011201 @default.
- W2169314089 cites W2065492264 @default.
- W2169314089 cites W2067995523 @default.
- W2169314089 cites W2070566940 @default.
- W2169314089 cites W2074306054 @default.
- W2169314089 cites W2080556515 @default.
- W2169314089 cites W2084535455 @default.
- W2169314089 cites W2085091196 @default.
- W2169314089 cites W2085680244 @default.
- W2169314089 cites W2086036400 @default.
- W2169314089 cites W2087076539 @default.
- W2169314089 cites W2087132310 @default.
- W2169314089 cites W2088093088 @default.
- W2169314089 cites W2094930349 @default.
- W2169314089 cites W2095268130 @default.
- W2169314089 cites W2095463569 @default.
- W2169314089 cites W2098039223 @default.
- W2169314089 cites W2106997862 @default.
- W2169314089 cites W2114033090 @default.
- W2169314089 cites W2114632806 @default.
- W2169314089 cites W2114640601 @default.
- W2169314089 cites W2116025461 @default.
- W2169314089 cites W2123355036 @default.
- W2169314089 cites W2125591445 @default.
- W2169314089 cites W2126153001 @default.
- W2169314089 cites W2129475346 @default.
- W2169314089 cites W2129754316 @default.
- W2169314089 cites W2135317303 @default.
- W2169314089 cites W2135601875 @default.
- W2169314089 cites W2138641438 @default.
- W2169314089 cites W2142126460 @default.
- W2169314089 cites W2147111725 @default.
- W2169314089 cites W2148959338 @default.
- W2169314089 cites W2152969853 @default.
- W2169314089 cites W2155187305 @default.
- W2169314089 cites W2163595098 @default.
- W2169314089 cites W2166549355 @default.
- W2169314089 cites W2172079625 @default.