FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169321777> ?p ?o ?g. }

• W2169321777 endingPage "681" @default.
• W2169321777 startingPage "669" @default.
• W2169321777 abstract "Different smooth muscle cell (SMC) functions may require different cell phenotypes. Because the main pulmonary artery performs diverse functions, we hypothesized that it would contain heterogeneous SMC populations. If the hypothesis were confirmed, we wished to determine the developmental origin of the different populations. Using specific antibodies, we analyzed the expression of smooth muscle (SM) contractile and cytoskeletal proteins (alpha-SM-actin, SM myosin, calponin, desmin, and meta-vinculin) in the main pulmonary artery of fetal (60 to 270 days of gestation), neonatal, and adult animals. We demonstrated the existence of a complex, site-specific heterogeneity in the structure and cellular composition of the pulmonary arterial wall. We found that at least four cell/SMC phenotypes, based on immunobiochemical characteristics, cell morphology, and elastic lamellae arrangement pattern, were simultaneously expressed within the mature arterial media. Further, we were able to assess phenotypic alterations in each of the four identified cell populations during development. We found that each cell population within the arterial media expressed alpha-SM-actin at least at certain stages of development, thus demonstrating its smooth muscle identity. However, each cell population progressed along different developmental pathways, suggesting the existence of multiple and distinct cell lineages. A novel anti-metavinculin antibody described in this study reliably distinguished one SMC population from the others during all the developmental stages analyzed. We conclude that the pulmonary arterial media is indeed composed of multiple phenotypically distinct cell/SMC populations with unique lineages. We speculate that these distinct cell populations may serve different functions within the arterial media and may also respond in unique ways to pathophysiological stimuli." @default.
• W2169321777 created "2016-06-24" @default.
• W2169321777 creator A5014076592 @default.
• W2169321777 creator A5071365469 @default.
• W2169321777 creator A5085362805 @default.
• W2169321777 date "1994-10-01" @default.
• W2169321777 modified "2023-10-15" @default.
• W2169321777 title "Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo." @default.
• W2169321777 cites W1486851320 @default.
• W2169321777 cites W1512716773 @default.
• W2169321777 cites W1554826971 @default.
• W2169321777 cites W1579521718 @default.
• W2169321777 cites W1606868561 @default.
• W2169321777 cites W1978404401 @default.
• W2169321777 cites W1980298637 @default.
• W2169321777 cites W2002527726 @default.
• W2169321777 cites W2009070341 @default.
• W2169321777 cites W2030522563 @default.
• W2169321777 cites W2031085260 @default.
• W2169321777 cites W2031128166 @default.
• W2169321777 cites W2034685050 @default.
• W2169321777 cites W2034771809 @default.
• W2169321777 cites W2040052703 @default.
• W2169321777 cites W2046539829 @default.
• W2169321777 cites W2047409154 @default.
• W2169321777 cites W2047434131 @default.
• W2169321777 cites W2053984681 @default.
• W2169321777 cites W2062449116 @default.
• W2169321777 cites W2062770053 @default.
• W2169321777 cites W2068471250 @default.
• W2169321777 cites W2069429113 @default.
• W2169321777 cites W2100837269 @default.
• W2169321777 cites W2101108802 @default.
• W2169321777 cites W2110720259 @default.
• W2169321777 cites W2115074637 @default.
• W2169321777 cites W2142457396 @default.
• W2169321777 cites W2170202796 @default.
• W2169321777 cites W2190010290 @default.
• W2169321777 cites W2223365691 @default.
• W2169321777 cites W2408598277 @default.
• W2169321777 cites W2465006970 @default.
• W2169321777 doi "https://doi.org/10.1161/01.res.75.4.669" @default.
• W2169321777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7923613" @default.
• W2169321777 hasPublicationYear "1994" @default.
• W2169321777 type Work @default.
• W2169321777 sameAs 2169321777 @default.
• W2169321777 citedByCount "207" @default.
• W2169321777 countsByYear W21693217772012 @default.
• W2169321777 countsByYear W21693217772013 @default.
• W2169321777 countsByYear W21693217772014 @default.
• W2169321777 countsByYear W21693217772015 @default.
• W2169321777 countsByYear W21693217772016 @default.
• W2169321777 countsByYear W21693217772017 @default.
• W2169321777 countsByYear W21693217772018 @default.
• W2169321777 countsByYear W21693217772019 @default.
• W2169321777 countsByYear W21693217772020 @default.
• W2169321777 countsByYear W21693217772021 @default.
• W2169321777 countsByYear W21693217772022 @default.
• W2169321777 countsByYear W21693217772023 @default.
• W2169321777 crossrefType "journal-article" @default.
• W2169321777 hasAuthorship W2169321777A5014076592 @default.
• W2169321777 hasAuthorship W2169321777A5071365469 @default.
• W2169321777 hasAuthorship W2169321777A5085362805 @default.
• W2169321777 hasBestOaLocation W21693217771 @default.
• W2169321777 hasConcept C104317684 @default.
• W2169321777 hasConcept C125705527 @default.
• W2169321777 hasConcept C127716648 @default.
• W2169321777 hasConcept C142669718 @default.
• W2169321777 hasConcept C142724271 @default.
• W2169321777 hasConcept C144024400 @default.
• W2169321777 hasConcept C147447768 @default.
• W2169321777 hasConcept C1491633281 @default.
• W2169321777 hasConcept C149923435 @default.
• W2169321777 hasConcept C189014844 @default.
• W2169321777 hasConcept C203014093 @default.
• W2169321777 hasConcept C204232928 @default.
• W2169321777 hasConcept C207200792 @default.
• W2169321777 hasConcept C2777979848 @default.
• W2169321777 hasConcept C2779072444 @default.
• W2169321777 hasConcept C2781122658 @default.
• W2169321777 hasConcept C2908647359 @default.
• W2169321777 hasConcept C54355233 @default.
• W2169321777 hasConcept C6997183 @default.
• W2169321777 hasConcept C71924100 @default.
• W2169321777 hasConcept C86803240 @default.
• W2169321777 hasConcept C95444343 @default.
• W2169321777 hasConceptScore W2169321777C104317684 @default.
• W2169321777 hasConceptScore W2169321777C125705527 @default.
• W2169321777 hasConceptScore W2169321777C127716648 @default.
• W2169321777 hasConceptScore W2169321777C142669718 @default.
• W2169321777 hasConceptScore W2169321777C142724271 @default.
• W2169321777 hasConceptScore W2169321777C144024400 @default.
• W2169321777 hasConceptScore W2169321777C147447768 @default.
• W2169321777 hasConceptScore W2169321777C1491633281 @default.
• W2169321777 hasConceptScore W2169321777C149923435 @default.
• W2169321777 hasConceptScore W2169321777C189014844 @default.
• W2169321777 hasConceptScore W2169321777C203014093 @default.
• W2169321777 hasConceptScore W2169321777C204232928 @default.

• next