Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169346661> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2169346661 endingPage "R5" @default.
- W2169346661 startingPage "R1" @default.
- W2169346661 abstract "Activin A is a member of the transforming growth factor-β family and has known roles in the adrenal cortex, from which activin A is secreted. We aimed to find whether activin A induces secretion of catecholamines from chromaffin cells of the adrenal medulla, which neighbours the adrenal cortex in vivo. Using carbon fibre amperometry, we were able to measure catecholamine secretion in real-time from single chromaffin cells dissociated from the rat adrenal medulla. Activin A stimulated catecholamine secretion in a rapid and dose-dependent manner from chromaffin cells. This effect was fully reversible upon washout of activin A. The minimum dose at which activin A had a maximal effect was 2 nM, with an EC 50 of 1.1 nM. The degree of secretion induced by activin A (2 nM) was smaller than that due to membrane depolarization caused by an increase in the external K + concentration from 5 to 70 mM. No response to activin A was seen when Ca 2+ channels were blocked by Cd 2+ (200 μM). We conclude from these findings that activin A is capable of stimulating a robust level of catecholamine secretion from adrenal chromaffin cells in a concentration-dependent manner. This occurs via the opening of voltage-gated Ca 2+ channels, causing Ca 2+ entry, thereby triggering exocytosis. These findings illustrate a new physiological role of activin A and a new mechanism in the control of catecholamine secretion from the adrenal medulla." @default.
- W2169346661 created "2016-06-24" @default.
- W2169346661 creator A5035952377 @default.
- W2169346661 creator A5063253432 @default.
- W2169346661 date "2005-08-01" @default.
- W2169346661 modified "2023-09-25" @default.
- W2169346661 title "Activin A stimulates catecholamine secretion from rat adrenal chromaffin cells: a new physiological mechanism" @default.
- W2169346661 cites W1971392630 @default.
- W2169346661 cites W1987063529 @default.
- W2169346661 cites W1993805456 @default.
- W2169346661 cites W1995609823 @default.
- W2169346661 cites W2033067408 @default.
- W2169346661 cites W2074895831 @default.
- W2169346661 cites W2079212114 @default.
- W2169346661 cites W2085291769 @default.
- W2169346661 cites W2085973839 @default.
- W2169346661 cites W2086918969 @default.
- W2169346661 cites W2094941012 @default.
- W2169346661 cites W2103031848 @default.
- W2169346661 cites W2154050788 @default.
- W2169346661 cites W2161607413 @default.
- W2169346661 doi "https://doi.org/10.1677/joe.1.06301" @default.
- W2169346661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16079252" @default.
- W2169346661 hasPublicationYear "2005" @default.
- W2169346661 type Work @default.
- W2169346661 sameAs 2169346661 @default.
- W2169346661 citedByCount "5" @default.
- W2169346661 countsByYear W21693466612012 @default.
- W2169346661 crossrefType "journal-article" @default.
- W2169346661 hasAuthorship W2169346661A5035952377 @default.
- W2169346661 hasAuthorship W2169346661A5063253432 @default.
- W2169346661 hasBestOaLocation W21693466611 @default.
- W2169346661 hasConcept C126322002 @default.
- W2169346661 hasConcept C134018914 @default.
- W2169346661 hasConcept C175969161 @default.
- W2169346661 hasConcept C185592680 @default.
- W2169346661 hasConcept C2775894120 @default.
- W2169346661 hasConcept C2777597313 @default.
- W2169346661 hasConcept C2780910648 @default.
- W2169346661 hasConcept C49039625 @default.
- W2169346661 hasConcept C71924100 @default.
- W2169346661 hasConcept C86803240 @default.
- W2169346661 hasConceptScore W2169346661C126322002 @default.
- W2169346661 hasConceptScore W2169346661C134018914 @default.
- W2169346661 hasConceptScore W2169346661C175969161 @default.
- W2169346661 hasConceptScore W2169346661C185592680 @default.
- W2169346661 hasConceptScore W2169346661C2775894120 @default.
- W2169346661 hasConceptScore W2169346661C2777597313 @default.
- W2169346661 hasConceptScore W2169346661C2780910648 @default.
- W2169346661 hasConceptScore W2169346661C49039625 @default.
- W2169346661 hasConceptScore W2169346661C71924100 @default.
- W2169346661 hasConceptScore W2169346661C86803240 @default.
- W2169346661 hasIssue "2" @default.
- W2169346661 hasLocation W21693466611 @default.
- W2169346661 hasLocation W21693466612 @default.
- W2169346661 hasOpenAccess W2169346661 @default.
- W2169346661 hasPrimaryLocation W21693466611 @default.
- W2169346661 hasRelatedWork W2019438272 @default.
- W2169346661 hasRelatedWork W2028955132 @default.
- W2169346661 hasRelatedWork W2038512896 @default.
- W2169346661 hasRelatedWork W2080670130 @default.
- W2169346661 hasRelatedWork W2136847233 @default.
- W2169346661 hasRelatedWork W2418456065 @default.
- W2169346661 hasRelatedWork W29093570 @default.
- W2169346661 hasRelatedWork W39316378 @default.
- W2169346661 hasRelatedWork W4242653623 @default.
- W2169346661 hasRelatedWork W76892265 @default.
- W2169346661 hasVolume "186" @default.
- W2169346661 isParatext "false" @default.
- W2169346661 isRetracted "false" @default.
- W2169346661 magId "2169346661" @default.
- W2169346661 workType "article" @default.