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- W2169348534 abstract "Mutations in cereblon (CRBN), a substrate binding component of the E3 ubiquitin ligase complex, cause a form of mental retardation in humans. However, the cellular proteins that interact with CRBN remain largely unknown. Here, we report that CRBN directly interacts with the α1 subunit of AMP-activated protein kinase (AMPK α1) and inhibits the activation of AMPK activation. The ectopic expression of CRBN reduces phosphorylation of AMPK α1 and, thus, inhibits the enzyme in a nutrient-independent manner. Moreover, AMPK α1 can be potently activated by suppressing endogenous CRBN using CRBN-specific small hairpin RNAs. Thus, CRBN may act as a negative modulator of the AMPK signaling pathway in vivo." @default.
- W2169348534 created "2016-06-24" @default.
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- W2169348534 date "2011-03-01" @default.
- W2169348534 modified "2023-10-16" @default.
- W2169348534 title "Functional modulation of AMP-activated protein kinase by cereblon" @default.
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- W2169348534 doi "https://doi.org/10.1016/j.bbamcr.2011.01.005" @default.
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