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• W2169353041 abstract "The goal of this study was to investigate the effect of sodium intake on renal tissue oxygenation in humans. To this purpose, we measured renal hemodynamics, renal sodium handling, and renal oxygenation in normotensive (NT) and hypertensive (HT) subjects after 1 week of a high-sodium and 1 week of a low-sodium diet. Renal oxygenation was measured using blood oxygen level–dependent magnetic resonance. Tissue oxygenation was determined by the measurement of R2* maps on 4 coronal slices covering both kidneys. The mean R2* values in the medulla and cortex were calculated, with a low R2* indicating a high tissue oxygenation. Ten male NT (mean age: 26.5±7.4 years) and 8 matched HT subjects (mean age: 28.8±5.7 years) were studied. Cortical R2* was not different under the 2 conditions of salt intake. Medullary R2* was significantly lower under low sodium than high sodium in both NT and HT subjects (28.1±0.8 versus 31.3±0.6 s −1 ; P <0.05 in NT; and 27.9±1.5 versus 30.3±0.8 s −1 ; P <0.05, in HT), indicating higher medullary oxygenation under low-sodium conditions. In NT subjects, medullary oxygenation was positively correlated with proximal reabsorption of sodium and negatively with absolute distal sodium reabsorption, but not with renal plasma flow. In HT subjects, medullary oxygenation correlated with the 24-hour sodium excretion but not with proximal or with the distal handling of sodium. These data demonstrate that dietary sodium intake influences renal tissue oxygenation, low sodium intake leading to an increased renal medullary oxygenation both in normotensive and young hypertensive subjects." @default.
• W2169353041 created "2016-06-24" @default.
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• W2169353041 date "2010-05-01" @default.
• W2169353041 modified "2023-10-16" @default.
• W2169353041 title "Effect of Sodium Loading/Depletion on Renal Oxygenation in Young Normotensive and Hypertensive Men" @default.
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• W2169353041 doi "https://doi.org/10.1161/hypertensionaha.109.149682" @default.
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