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• W2169355083 abstract "Nuclear medicine techniques are well established for the investigation of gastrointestinal (GI) motility and transit. Ion-exchange resins radiolabelled with 99mTc and 111In are widely used as nonabsorbable radiopharmaceutical markers, with 111In being preferred for whole-gut transit studies. This radionuclide, however, is not produced in many countries and may be expensive when obtained through international shipment. This study describes the use of neutron-activated 153Sm-resin as an alternative tracer for use in GI scintigraphic investigation. A measure of 50 mg of stable samarium-152 chloride (152SmCl3) was incorporated into 100 mg of cation-exchange resin and irradiated in a neutron flux of 1×1013 cm−2 s−1 for 100 s to achieve an activity of 5 MBq after 66 h. Aliquots of 111In-radiolabelled resin (5 MBq) were prepared for comparison of labelling and stability. Radiolabelling efficiencies were obtained by washing resin with distilled water, and the activity lost was measured. The radiolabelled resins were immersed in simulated gastric and intestinal fluid environments, and the retention of 153Sm3+ and 111In3+ was measured over a 24 h period. At 66 h after production, 91.15±12.42% of 153Sm was bound to the resin after washing in distilled water, whereas radiolabelling with 111In achieved 99.96±0.02% efficiency. Both radiolabelled resins demonstrated almost 100% stability in simulated intestinal fluid and >90% stability in artificial gastric juice over 24 h. The performance of neutron-activated 153Sm-resin is similar to that of 111In-resin and can be used as an alternative tracer for GI transit studies when 111In is not available." @default.
• W2169355083 created "2016-06-24" @default.
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• W2169355083 date "2011-12-01" @default.
• W2169355083 modified "2023-10-16" @default.
• W2169355083 title "Neutron-activated 153Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy" @default.
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• W2169355083 doi "https://doi.org/10.1097/mnm.0b013e32834b3ac8" @default.
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