Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169355589> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2169355589 endingPage "1231" @default.
- W2169355589 startingPage "1227" @default.
- W2169355589 abstract "A phase study of the intralesional administration of ricin-labelled monoclonal antibodies was conducted in patients with hepatic metastases of gastrointestinal origin. The anti-carcinoembryonic antigen (CEA) antibody I-1 was conjugated to blocked ricin via a disulphide bridge. After a test dose of antibody, patients were injected with ricin-antibody conjugates under computed tomography (CT) guidance on two occasions 1 week apart. Patients with stable or responding disease would receive a third course. The dose of ricin relative to surface area was increased in a predefined manner in cohorts of 3 patients. A total of 27 patients with hepatic metastases were entered into this study. All patients had metastatic colorectal cancer (26 patients) or adenocarcinoma of unknown primary with elevated CEA levels (1 patient). The presence of malignancy was documented cytologically in 9 of 11 patients tested. Minor responses were seen in 7 patients. However, no major objective responses or changes in the growth rate of injected lesions were observed. Toxicity was generally mild, the most common being hepatic capsular pain 24–48 h after each injection. 6 patients experienced rigors. One patient had anaphylaxis. Human anti-mouse and anti-ricin antibody responses were observed. Although substantial amounts of ricin conjugated to monoclonal antibodies were delivered into single lesions, this therapeutic approach was unsuccessful. Future studies of ricin-labelled antibodies should incorporate the systemic administration of immunoconjugates." @default.
- W2169355589 created "2016-06-24" @default.
- W2169355589 creator A5008173055 @default.
- W2169355589 creator A5017980678 @default.
- W2169355589 creator A5028909942 @default.
- W2169355589 creator A5034239292 @default.
- W2169355589 creator A5054416511 @default.
- W2169355589 creator A5058900172 @default.
- W2169355589 creator A5069340852 @default.
- W2169355589 creator A5073227620 @default.
- W2169355589 creator A5074004806 @default.
- W2169355589 date "1994-01-01" @default.
- W2169355589 modified "2023-10-15" @default.
- W2169355589 title "A phase study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases" @default.
- W2169355589 cites W1978553713 @default.
- W2169355589 cites W1993885156 @default.
- W2169355589 cites W2015819915 @default.
- W2169355589 cites W2023411546 @default.
- W2169355589 cites W2033050305 @default.
- W2169355589 cites W2061475241 @default.
- W2169355589 cites W2074783652 @default.
- W2169355589 cites W2268936782 @default.
- W2169355589 doi "https://doi.org/10.1016/0959-8049(94)90163-5" @default.
- W2169355589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7999404" @default.
- W2169355589 hasPublicationYear "1994" @default.
- W2169355589 type Work @default.
- W2169355589 sameAs 2169355589 @default.
- W2169355589 citedByCount "22" @default.
- W2169355589 countsByYear W21693555892012 @default.
- W2169355589 countsByYear W21693555892013 @default.
- W2169355589 countsByYear W21693555892014 @default.
- W2169355589 countsByYear W21693555892020 @default.
- W2169355589 countsByYear W21693555892021 @default.
- W2169355589 crossrefType "journal-article" @default.
- W2169355589 hasAuthorship W2169355589A5008173055 @default.
- W2169355589 hasAuthorship W2169355589A5017980678 @default.
- W2169355589 hasAuthorship W2169355589A5028909942 @default.
- W2169355589 hasAuthorship W2169355589A5034239292 @default.
- W2169355589 hasAuthorship W2169355589A5054416511 @default.
- W2169355589 hasAuthorship W2169355589A5058900172 @default.
- W2169355589 hasAuthorship W2169355589A5069340852 @default.
- W2169355589 hasAuthorship W2169355589A5073227620 @default.
- W2169355589 hasAuthorship W2169355589A5074004806 @default.
- W2169355589 hasConcept C121608353 @default.
- W2169355589 hasConcept C126322002 @default.
- W2169355589 hasConcept C142724271 @default.
- W2169355589 hasConcept C159654299 @default.
- W2169355589 hasConcept C203014093 @default.
- W2169355589 hasConcept C2777200438 @default.
- W2169355589 hasConcept C2777367657 @default.
- W2169355589 hasConcept C2777387746 @default.
- W2169355589 hasConcept C542903549 @default.
- W2169355589 hasConcept C55493867 @default.
- W2169355589 hasConcept C71924100 @default.
- W2169355589 hasConcept C86803240 @default.
- W2169355589 hasConcept C90924648 @default.
- W2169355589 hasConceptScore W2169355589C121608353 @default.
- W2169355589 hasConceptScore W2169355589C126322002 @default.
- W2169355589 hasConceptScore W2169355589C142724271 @default.
- W2169355589 hasConceptScore W2169355589C159654299 @default.
- W2169355589 hasConceptScore W2169355589C203014093 @default.
- W2169355589 hasConceptScore W2169355589C2777200438 @default.
- W2169355589 hasConceptScore W2169355589C2777367657 @default.
- W2169355589 hasConceptScore W2169355589C2777387746 @default.
- W2169355589 hasConceptScore W2169355589C542903549 @default.
- W2169355589 hasConceptScore W2169355589C55493867 @default.
- W2169355589 hasConceptScore W2169355589C71924100 @default.
- W2169355589 hasConceptScore W2169355589C86803240 @default.
- W2169355589 hasConceptScore W2169355589C90924648 @default.
- W2169355589 hasIssue "9" @default.
- W2169355589 hasLocation W21693555891 @default.
- W2169355589 hasLocation W21693555892 @default.
- W2169355589 hasOpenAccess W2169355589 @default.
- W2169355589 hasPrimaryLocation W21693555891 @default.
- W2169355589 hasRelatedWork W1076776651 @default.
- W2169355589 hasRelatedWork W1494324954 @default.
- W2169355589 hasRelatedWork W1999686187 @default.
- W2169355589 hasRelatedWork W2053311667 @default.
- W2169355589 hasRelatedWork W2086907967 @default.
- W2169355589 hasRelatedWork W2762212335 @default.
- W2169355589 hasRelatedWork W2794160073 @default.
- W2169355589 hasRelatedWork W3125527754 @default.
- W2169355589 hasRelatedWork W4241351734 @default.
- W2169355589 hasRelatedWork W4312623967 @default.
- W2169355589 hasVolume "30" @default.
- W2169355589 isParatext "false" @default.
- W2169355589 isRetracted "false" @default.
- W2169355589 magId "2169355589" @default.
- W2169355589 workType "article" @default.