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- W2169358445 abstract "The association of specific events with the context in which they occur is a fundamental feature of episodic memory. However, the underlying network mechanisms generating what–where associations are poorly understood. Recently we reported that some hippocampal principal neurons develop representations of specific events occurring in particular locations (item-position cells). Here, we investigate the emergence of item-position selectivity as rats learn new associations for reward and find that before the animal's performance rises above chance in the task, neurons that will later become item-position cells have a strong selective bias toward one of two behavioral responses, which the animal will subsequently make to that stimulus. This response bias results in an asymmetry of neural activity on correct and error trials that could drive the emergence of particular item specificities based on a simple reward-driven synaptic plasticity mechanism." @default.
- W2169358445 created "2016-06-24" @default.
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- W2169358445 date "2011-10-21" @default.
- W2169358445 modified "2023-09-27" @default.
- W2169358445 title "A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where" @default.
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- W2169358445 doi "https://doi.org/10.1101/lm.2307711" @default.
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