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- W2169363649 abstract "Spinal muscular atrophy is a neuromuscular disease resulting from mutations in the SMN1 gene, which encodes the survival motor neuron (SMN) protein. SMN is part of a large complex that is essential for the biogenesis of spliceosomal small nuclear RNPs. SMN also colocalizes with mRNAs in granules that are actively transported in neuronal processes, supporting the hypothesis that SMN is involved in axonal trafficking of mRNPs. Here, we have performed a genome-wide analysis of RNAs present in complexes containing the SMN protein and identified more than 200 mRNAs associated with SMN in differentiated NSC-34 motor neuron-like cells. Remarkably, ∼30% are described to localize in axons of different neuron types. In situ hybridization and immuno-fluorescence experiments performed on several candidates indicate that these mRNAs colocalize with the SMN protein in neurites and axons of differentiated NSC-34 cells. Moreover, they localize in cell processes in an SMN-dependent manner. Thus, low SMN levels might result in localization deficiencies of mRNAs required for axonogenesis." @default.
- W2169363649 created "2016-06-24" @default.
- W2169363649 creator A5000822904 @default.
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- W2169363649 creator A5059662534 @default.
- W2169363649 date "2013-10-23" @default.
- W2169363649 modified "2023-10-18" @default.
- W2169363649 title "Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization" @default.
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- W2169363649 doi "https://doi.org/10.1261/rna.040204.113" @default.
- W2169363649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3884661" @default.
- W2169363649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24152552" @default.
- W2169363649 hasPublicationYear "2013" @default.
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