FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169363911> ?p ?o ?g. }

• W2169363911 abstract "Orbital inflammation is common, but the mechanisms underlying leucocytic infiltration of orbital tissue are poorly understood. Human orbital fibroblasts (OF) express chemokines, interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1), when exposed to proinflammatory cytokines. The effect of dexamethasone (DEX) and cyclosporin A (CSA) on OF IL-8 and MCP-1 were examined.Cultured human OF were incubated with recombinant interleukin 1 beta (rIL-1 beta; 0.2, 2.0, 20 ng/ml) alone or incubated with rIL-1 beta and DEX (10(-8), 10(-7), 10(-6) M) or CSA (3, 30, 300 ng/ml) for 24 hours. ELISA and northern blot analyses were performed to determine OF IL-8 and MCP-1 protein secretion and mRNA expression, respectively.OF lacked constitutive IL-8 or MCP-1 expression, but secreted significant amounts of these chemokines and expressed substantial steady state mRNA for both chemokines upon rIL-1 beta stimulation. DEX caused dose dependent inhibition of IL-1 induced IL-8 (p < 0.001) and MCP-1 (p < 0.05) secretion and mRNA expression at all concentrations of rIL-1 beta. CSA enhanced IL-1 induced OF IL-8 (p < 0.001) and suppressed rIL-1 beta induced OF MCP-1 (p < 0.05) secretion when lower doses of rIL-1 beta were used. These effects on secreted chemokines at different concentrations of rIL-1 beta and immunomodulating agents were corroborated by steady state OF IL-8 and MCP-1 mRNA expression.DEX is a potent inhibitor of OF IL-8 and MCP-1. In contrast, CSA enhances IL-1 induced OF IL-8 and suppresses OF MCP-1. These observations may explain the relative lack of CSA effectiveness in human orbital diseases that respond to corticosteroids." @default.
• W2169363911 created "2016-06-24" @default.
• W2169363911 creator A5049627780 @default.
• W2169363911 creator A5068395003 @default.
• W2169363911 creator A5082567021 @default.
• W2169363911 date "1998-03-01" @default.
• W2169363911 modified "2023-10-03" @default.
• W2169363911 title "Orbital fibroblast chemokine modulation: effects of dexamethasone and cyclosporin A" @default.
• W2169363911 cites W118472439 @default.
• W2169363911 cites W139608630 @default.
• W2169363911 cites W143716505 @default.
• W2169363911 cites W1504900014 @default.
• W2169363911 cites W1605014691 @default.
• W2169363911 cites W1605711455 @default.
• W2169363911 cites W1780460389 @default.
• W2169363911 cites W1972014048 @default.
• W2169363911 cites W1988798314 @default.
• W2169363911 cites W1994394844 @default.
• W2169363911 cites W1995393576 @default.
• W2169363911 cites W2005098949 @default.
• W2169363911 cites W2029467498 @default.
• W2169363911 cites W2050363126 @default.
• W2169363911 cites W2052616604 @default.
• W2169363911 cites W2057233459 @default.
• W2169363911 cites W2060333964 @default.
• W2169363911 cites W2063392913 @default.
• W2169363911 cites W2069079534 @default.
• W2169363911 cites W2082745336 @default.
• W2169363911 cites W2084932615 @default.
• W2169363911 cites W2092784256 @default.
• W2169363911 cites W2123090800 @default.
• W2169363911 cites W2125762952 @default.
• W2169363911 cites W2159833023 @default.
• W2169363911 cites W2176220887 @default.
• W2169363911 cites W2332804073 @default.
• W2169363911 cites W2413740671 @default.
• W2169363911 cites W2414619593 @default.
• W2169363911 cites W2416897117 @default.
• W2169363911 cites W2417442959 @default.
• W2169363911 doi "https://doi.org/10.1136/bjo.82.3.318" @default.
• W2169363911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1722500" @default.
• W2169363911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9602633" @default.
• W2169363911 hasPublicationYear "1998" @default.
• W2169363911 type Work @default.
• W2169363911 sameAs 2169363911 @default.
• W2169363911 citedByCount "14" @default.
• W2169363911 countsByYear W21693639112012 @default.
• W2169363911 countsByYear W21693639112017 @default.
• W2169363911 countsByYear W21693639112018 @default.
• W2169363911 countsByYear W21693639112019 @default.
• W2169363911 crossrefType "journal-article" @default.
• W2169363911 hasAuthorship W2169363911A5049627780 @default.
• W2169363911 hasAuthorship W2169363911A5068395003 @default.
• W2169363911 hasAuthorship W2169363911A5082567021 @default.
• W2169363911 hasBestOaLocation W21693639111 @default.
• W2169363911 hasConcept C104317684 @default.
• W2169363911 hasConcept C105580179 @default.
• W2169363911 hasConcept C126322002 @default.
• W2169363911 hasConcept C13373296 @default.
• W2169363911 hasConcept C134018914 @default.
• W2169363911 hasConcept C153911025 @default.
• W2169363911 hasConcept C164027704 @default.
• W2169363911 hasConcept C177707886 @default.
• W2169363911 hasConcept C199360897 @default.
• W2169363911 hasConcept C2776174256 @default.
• W2169363911 hasConcept C2776914184 @default.
• W2169363911 hasConcept C2778690821 @default.
• W2169363911 hasConcept C2780401358 @default.
• W2169363911 hasConcept C2781184567 @default.
• W2169363911 hasConcept C41008148 @default.
• W2169363911 hasConcept C49039625 @default.
• W2169363911 hasConcept C55493867 @default.
• W2169363911 hasConcept C68324877 @default.
• W2169363911 hasConcept C71924100 @default.
• W2169363911 hasConcept C74172505 @default.
• W2169363911 hasConcept C86803240 @default.
• W2169363911 hasConceptScore W2169363911C104317684 @default.
• W2169363911 hasConceptScore W2169363911C105580179 @default.
• W2169363911 hasConceptScore W2169363911C126322002 @default.
• W2169363911 hasConceptScore W2169363911C13373296 @default.
• W2169363911 hasConceptScore W2169363911C134018914 @default.
• W2169363911 hasConceptScore W2169363911C153911025 @default.
• W2169363911 hasConceptScore W2169363911C164027704 @default.
• W2169363911 hasConceptScore W2169363911C177707886 @default.
• W2169363911 hasConceptScore W2169363911C199360897 @default.
• W2169363911 hasConceptScore W2169363911C2776174256 @default.
• W2169363911 hasConceptScore W2169363911C2776914184 @default.
• W2169363911 hasConceptScore W2169363911C2778690821 @default.
• W2169363911 hasConceptScore W2169363911C2780401358 @default.
• W2169363911 hasConceptScore W2169363911C2781184567 @default.
• W2169363911 hasConceptScore W2169363911C41008148 @default.
• W2169363911 hasConceptScore W2169363911C49039625 @default.
• W2169363911 hasConceptScore W2169363911C55493867 @default.
• W2169363911 hasConceptScore W2169363911C68324877 @default.
• W2169363911 hasConceptScore W2169363911C71924100 @default.
• W2169363911 hasConceptScore W2169363911C74172505 @default.
• W2169363911 hasConceptScore W2169363911C86803240 @default.
• W2169363911 hasLocation W21693639111 @default.
• W2169363911 hasLocation W21693639112 @default.
• W2169363911 hasLocation W21693639113 @default.

• next