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- W2169366197 abstract "Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligand-independent signaling by the precursors of mature antigen receptors regulates development of B and T lymphocytes. Here we describe a basal signal that controls gene expression profiles in the Jurkat T cell line and mouse thymocytes. Using DNA microarrays and Northern blots to analyze unstimulated cells, we demonstrate that expression of a cluster of genes, including RAG-1 and RAG-2, is repressed by constitutive signals requiring the adapter molecules LAT and SLP-76. This TCR-like pathway results in constitutive low-level activity of Erk and Abl kinases. Inhibition of Abl by the drug STI-571 or inhibition of signaling events upstream of Erk increases RAG-1 expression. Our data suggest that physiologic gene expression programs depend upon tonic activity of signaling pathways independent of receptor ligation." @default.
- W2169366197 created "2016-06-24" @default.
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- W2169366197 date "2003-11-17" @default.
- W2169366197 modified "2023-09-26" @default.
- W2169366197 title "T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression" @default.
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- W2169366197 doi "https://doi.org/10.1371/journal.pbio.0000053" @default.
- W2169366197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/261890" @default.
- W2169366197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14624253" @default.