FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169368809> ?p ?o ?g. }

• W2169368809 abstract "Abstract Background Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. In this study, we have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice. Methods BALB/c mice were sensitized and challenged (primary) with ovalbumin (OVA). Six weeks later, a single OVA aerosol (secondary challenge) was delivered and airway inflammation and airway responses were monitored 6 and 48 hrs later. An inhibitor of neutrophil elastase was administered prior to secondary challenge. Results Mice developed a two-phase airway inflammatory response after secondary allergen challenge, one neutrophilic at 6 hr and the other eosinophilic, at 48 hr. PAR-2 expression in the lung tissues was enhanced following secondary challenge, and that PAR-2 intracellular expression on peribronchial lymph node (PBLN) T cells was also increased following allergen challenge of sensitized mice. Inhibition of neutrophil elastase significantly attenuated AHR, goblet cell metaplasia, and inflammatory cell accumulation in the airways following secondary OVA challenge. Levels of IL-4, IL-5 and IL-13, and eotaxin in BAL fluid 6 hr after secondary allergen challenge were significantly suppressed by the treatment. At 48 hr, treatment with the neutrophil elastase inhibitor significantly reduced the levels of IL-13 and TGF-β1 in the BAL fluid. In parallel, in vitro IL-13 production was significantly inhibited in spleen cells from sensitized mice. Conclusion These data indicate that neutrophil elastase plays an important role in the development of allergic airway inflammation and hyperresponsiveness, and would suggest that the neutrophil elastase inhibitor reduced AHR to inhaled methacholine indicating the potential for its use as a modulator of the immune/inflammatory response in both the neutrophil- and eosinophil-dominant phases of the response to secondary allergen challenge." @default.
• W2169368809 created "2016-06-24" @default.
• W2169368809 creator A5007888883 @default.
• W2169368809 creator A5011430982 @default.
• W2169368809 creator A5016460192 @default.
• W2169368809 creator A5023960478 @default.
• W2169368809 creator A5035266702 @default.
• W2169368809 creator A5040728443 @default.
• W2169368809 creator A5052680962 @default.
• W2169368809 creator A5054024599 @default.
• W2169368809 creator A5077880103 @default.
• W2169368809 creator A5090286024 @default.
• W2169368809 creator A5090296046 @default.
• W2169368809 date "2013-01-24" @default.
• W2169368809 modified "2023-10-16" @default.
• W2169368809 title "Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses" @default.
• W2169368809 cites W1494505798 @default.
• W2169368809 cites W1642728877 @default.
• W2169368809 cites W1811402656 @default.
• W2169368809 cites W1860345345 @default.
• W2169368809 cites W1945512486 @default.
• W2169368809 cites W1963751483 @default.
• W2169368809 cites W1966738621 @default.
• W2169368809 cites W1974649266 @default.
• W2169368809 cites W1977008844 @default.
• W2169368809 cites W1982342687 @default.
• W2169368809 cites W1986832053 @default.
• W2169368809 cites W1987492687 @default.
• W2169368809 cites W1991724765 @default.
• W2169368809 cites W1991965285 @default.
• W2169368809 cites W1992622607 @default.
• W2169368809 cites W1994142025 @default.
• W2169368809 cites W2003133523 @default.
• W2169368809 cites W2003374787 @default.
• W2169368809 cites W2006386088 @default.
• W2169368809 cites W2008204167 @default.
• W2169368809 cites W2030152720 @default.
• W2169368809 cites W2040951215 @default.
• W2169368809 cites W2041385557 @default.
• W2169368809 cites W2045873742 @default.
• W2169368809 cites W2047267265 @default.
• W2169368809 cites W2053208368 @default.
• W2169368809 cites W2054326672 @default.
• W2169368809 cites W2057125179 @default.
• W2169368809 cites W2059654627 @default.
• W2169368809 cites W2068589685 @default.
• W2169368809 cites W2070550392 @default.
• W2169368809 cites W2086782209 @default.
• W2169368809 cites W2093017152 @default.
• W2169368809 cites W2101664092 @default.
• W2169368809 cites W2106692330 @default.
• W2169368809 cites W2116161600 @default.
• W2169368809 cites W2118306607 @default.
• W2169368809 cites W2122738080 @default.
• W2169368809 cites W2136953421 @default.
• W2169368809 cites W2140792600 @default.
• W2169368809 cites W2141603531 @default.
• W2169368809 cites W2147759125 @default.
• W2169368809 cites W2152286148 @default.
• W2169368809 cites W2152896092 @default.
• W2169368809 cites W2155416811 @default.
• W2169368809 cites W2159406978 @default.
• W2169368809 cites W2161068101 @default.
• W2169368809 cites W2161938158 @default.
• W2169368809 cites W2167272322 @default.
• W2169368809 doi "https://doi.org/10.1186/1465-9921-14-8" @default.
• W2169368809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3570429" @default.
• W2169368809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23347423" @default.
• W2169368809 hasPublicationYear "2013" @default.
• W2169368809 type Work @default.
• W2169368809 sameAs 2169368809 @default.
• W2169368809 citedByCount "51" @default.
• W2169368809 countsByYear W21693688092013 @default.
• W2169368809 countsByYear W21693688092014 @default.
• W2169368809 countsByYear W21693688092015 @default.
• W2169368809 countsByYear W21693688092016 @default.
• W2169368809 countsByYear W21693688092017 @default.
• W2169368809 countsByYear W21693688092018 @default.
• W2169368809 countsByYear W21693688092019 @default.
• W2169368809 countsByYear W21693688092020 @default.
• W2169368809 countsByYear W21693688092021 @default.
• W2169368809 countsByYear W21693688092022 @default.
• W2169368809 countsByYear W21693688092023 @default.
• W2169368809 crossrefType "journal-article" @default.
• W2169368809 hasAuthorship W2169368809A5007888883 @default.
• W2169368809 hasAuthorship W2169368809A5011430982 @default.
• W2169368809 hasAuthorship W2169368809A5016460192 @default.
• W2169368809 hasAuthorship W2169368809A5023960478 @default.
• W2169368809 hasAuthorship W2169368809A5035266702 @default.
• W2169368809 hasAuthorship W2169368809A5040728443 @default.
• W2169368809 hasAuthorship W2169368809A5052680962 @default.
• W2169368809 hasAuthorship W2169368809A5054024599 @default.
• W2169368809 hasAuthorship W2169368809A5077880103 @default.
• W2169368809 hasAuthorship W2169368809A5090286024 @default.
• W2169368809 hasAuthorship W2169368809A5090296046 @default.
• W2169368809 hasBestOaLocation W21693688091 @default.
• W2169368809 hasConcept C126322002 @default.
• W2169368809 hasConcept C181199279 @default.
• W2169368809 hasConcept C185592680 @default.
• W2169368809 hasConcept C203014093 @default.

• next