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• W2169372011 abstract "Immunocytochemical techniques were employed in order to examine the distribution and relative intensity of the AMPA receptor subunits GluR1 and GluR2/3 within the hippocampal formation of normal controls and Alzheimer's disease (AD) cases. Throughout our investigation we examined cases exhibiting a wide range of pathologic severity, thus allowing us to correlate our immunohistochemical data with the extent of pathology. Specifically, we investigated the distribution of these receptor subunits in hippocampal sectors that are particularly vulnerable to AD pathology (i. e., CA1 and subiculum) and compared these findings with those obtained following examination of sectors that are generally resistant to pathologic change (i. e., CA2/3, dentate gyrus). Within vulnerable sectors we observed a variable loss of GluR1 and GluR2/3 immunolabeling. The degree to which these proteins were reduced appeared to correlate with the extent of neurofibrillary pathology and cell loss. Despite the loss of labeled cells, the intensity of immunolabeling within the remaining neurons was comparable with, and in many instances even greater than, that observed in control cases. Within resistant sectors, the distribution of immunoreactive elements was comparable in both case groups yet the intensity of immunolabeling was markedly increased in AD cases, particularly in the molecular layer of the dentate gyrus and in the stratum lucidum of CA3 (i. e., the termination zones of perforant pathway and mossy fibers). In addition, within AD cases dramatic increases were observed within the supragranular and polymorphic layer of the dentate gyrus (i. e., the terminal zones of sprouting mossy fiber collaterals). The increase in GluR1 and GluR2/3 immunolabeling is hypothesized to occur in response to the deafferentation of selected glutamatergic pathways. Moreover, our data support that hippocampal plasticity is preserved, even in severe AD cases, and suggest a critical role for AMPA receptor subunits in this plasticity and in maintaining hippocampal functioning. © 1995 Wiley-Liss, Inc." @default.
• W2169372011 created "2016-06-24" @default.
• W2169372011 creator A5000814979 @default.
• W2169372011 creator A5001066277 @default.
• W2169372011 creator A5021171640 @default.
• W2169372011 date "1995-01-01" @default.
• W2169372011 modified "2023-09-27" @default.
• W2169372011 title "AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal formation of patients with Alzheimer's disease" @default.
• W2169372011 cites W1548600249 @default.
• W2169372011 cites W1551261730 @default.
• W2169372011 cites W1556569805 @default.
• W2169372011 cites W1556707181 @default.
• W2169372011 cites W1603732963 @default.
• W2169372011 cites W1728222780 @default.
• W2169372011 cites W1963895777 @default.
• W2169372011 cites W1966681799 @default.
• W2169372011 cites W1969363559 @default.
• W2169372011 cites W1969455604 @default.
• W2169372011 cites W1972614082 @default.
• W2169372011 cites W1975098006 @default.
• W2169372011 cites W1976651454 @default.
• W2169372011 cites W1977529115 @default.
• W2169372011 cites W1979037634 @default.
• W2169372011 cites W1980642537 @default.
• W2169372011 cites W1981964626 @default.
• W2169372011 cites W1983948601 @default.
• W2169372011 cites W1985221567 @default.
• W2169372011 cites W1986130768 @default.
• W2169372011 cites W1987376653 @default.
• W2169372011 cites W1989851175 @default.
• W2169372011 cites W1992665922 @default.
• W2169372011 cites W1992827246 @default.
• W2169372011 cites W1997720394 @default.
• W2169372011 cites W1999968276 @default.
• W2169372011 cites W2001148365 @default.
• W2169372011 cites W2002214235 @default.
• W2169372011 cites W2002360249 @default.
• W2169372011 cites W2003439867 @default.
• W2169372011 cites W2004803322 @default.
• W2169372011 cites W2010928535 @default.
• W2169372011 cites W2014584100 @default.
• W2169372011 cites W2016065995 @default.
• W2169372011 cites W2016602177 @default.
• W2169372011 cites W2020121689 @default.
• W2169372011 cites W2022523348 @default.
• W2169372011 cites W2023349854 @default.
• W2169372011 cites W2023692020 @default.
• W2169372011 cites W202677935 @default.
• W2169372011 cites W2033607722 @default.
• W2169372011 cites W2034015123 @default.
• W2169372011 cites W2038471077 @default.
• W2169372011 cites W2039493798 @default.
• W2169372011 cites W2040863767 @default.
• W2169372011 cites W2041296128 @default.
• W2169372011 cites W2041644100 @default.
• W2169372011 cites W2047065428 @default.
• W2169372011 cites W2048795056 @default.
• W2169372011 cites W2052480517 @default.
• W2169372011 cites W2053794612 @default.
• W2169372011 cites W2053980736 @default.
• W2169372011 cites W2054683291 @default.
• W2169372011 cites W2056025481 @default.
• W2169372011 cites W2058663262 @default.
• W2169372011 cites W2060084946 @default.
• W2169372011 cites W2063200839 @default.
• W2169372011 cites W2063461600 @default.
• W2169372011 cites W2066310482 @default.
• W2169372011 cites W2069835093 @default.
• W2169372011 cites W2071006250 @default.
• W2169372011 cites W2071992850 @default.
• W2169372011 cites W2075395362 @default.
• W2169372011 cites W2080589549 @default.
• W2169372011 cites W2084369020 @default.
• W2169372011 cites W2084936042 @default.
• W2169372011 cites W2090716323 @default.
• W2169372011 cites W2090872672 @default.
• W2169372011 cites W2092269192 @default.
• W2169372011 cites W2093783490 @default.
• W2169372011 cites W2099597342 @default.
• W2169372011 cites W2119146982 @default.
• W2169372011 cites W2129108032 @default.
• W2169372011 cites W2139260459 @default.
• W2169372011 cites W2147488068 @default.
• W2169372011 cites W2158717151 @default.
• W2169372011 cites W2167355911 @default.
• W2169372011 cites W2171405125 @default.
• W2169372011 cites W2194738929 @default.
• W2169372011 cites W2320522173 @default.
• W2169372011 cites W2341354469 @default.
• W2169372011 cites W2580821419 @default.
• W2169372011 cites W2882995397 @default.
• W2169372011 cites W4253249436 @default.
• W2169372011 doi "https://doi.org/10.1002/hipo.450050509" @default.
• W2169372011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8773259" @default.
• W2169372011 hasPublicationYear "1995" @default.
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