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- W2169373965 abstract "Altundag and colleagues suggest that obese women have an increased breast cancer risk due to a longer reproductive life. A meta-analysis of 23 studies providing information on body mass index incidence in premenopausal breast cancer has shown an inverse association between obesity and breast cancer [1.Ursin G. Longnecker M.P. Haile R.W. Greenland S. A meta-analysis of body mass index and risk of premenopausal breast cancer.Epidemiology. 1995; 6: 137-141Crossref PubMed Scopus (207) Google Scholar]. These results have been confirmed in the large US female nurses cohort [2.Huang Z. Hankinson S.E. Colditz G.A. et al.Dual effects of weight and weight gain on breast cancer risk.JAMA. 1997; 278: 1448-1449Crossref Scopus (698) Google Scholar]. In a prospective evaluation about relative weight on the occurrence of natural menopause, no association could be demonstrated between obesity and a delayed menopause [3.Willett W. Stampfer M.J. Bain C. et al.Cigarette smoking, relative weight.and menopause. Am J Epidemiol. 1983; 117: 651-658Crossref PubMed Scopus (493) Google Scholar]. We agree with Altundag and colleagues that the role of obesity in the development of amenorrhea after chemotherapy needs to be evaluated in larger studies as in the quoted publication of Mehta et al. [4.Mehta R.R. Beattie C.W. Das Gupta T.K. Endocrine profile in breast cancer patients receiving chemotherapy.Breast Cancer Res Treat. 1992; 20: 125-132Crossref PubMed Scopus (60) Google Scholar], in which the number of patients [37 of 46 (80%) non-obese and 17 of 24 (71%) obese women became amenorrheic] was much too small to draw any conclusions (P = 0.84)." @default.
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- W2169373965 date "2005-02-01" @default.
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- W2169373965 title "Reply to the Letter to the Editor on “Obesity may decrease the amenorrhea associated with chemotherapy in premenopausal breast cancer patients”, by K. Altundag et al. (Ann Oncol 2005; 16: 333)" @default.
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- W2169373965 doi "https://doi.org/10.1093/annonc/mdi045" @default.
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